Bench, Bedside, Business, and Beyond: innovative solutions for AMR diagnostics

实验室、床边、商业及其他：AMR 诊断的创新解决方案

• 批准号: MR/X036936/1
• 负责人: Leonid Chindelevitch
• 金额: $ 5.62万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX036936%2F1
• 关键词: Bench; Bedside; Business; Beyond; innovative

The network, B2B2B AMRDx, brings together a diverse group of researchers from universities (bench), hospitals (bedside), for-profits (business), governments and nonprofits (beyond), to tackle some of these challenges. We have expertise in human, animal, and environmental AMR, and come from 20 different countries. The networks goals are as follows.First, the network creates a comprehensive online AMR Diagnostics Developer Directory (ADDD) to facilitate exchange of ideas in the field. Second, the network extends the JPIAMR Seq4AMR Virtual Benchmarking Platform (VBP) to allow diagnostics developers to systematically evaluate their diagnostics on a collection of high-quality genotypes (genomic data) and phenotypes (antimicrobial resistance data) and identify their strengths and weaknesses. Third, the network identifies new policy directions that can support diagnostics development and adoption by accounting for the public health benefits of using AMR diagnostics. These developments will help AMR diagnostics cross the "valley of death" and help patients.Expected outcomes:An open, curated online AMR diagnostics developer directory (ADDD), building on AMR Insights' Technology Pages.A workshop to develop the standards for genotypes, phenotypes, and metadata, as well as the accompanying bacterial isolates for the VBP, building on previous achievements of the Seq4AMR network (Raphenya et al, 2022)A systematic approach for the management, selection and curation of gold standard NGS data, phenotype data, and metadata, as well as the corresponding bacterial isolates for the VBP.Communication, dissemination and roadmap open-access publication describing the VBP contents, its format, and the benchmark set selection protocol. Possible journals: Microbial Genomics or similar.A workshop to develop a proposal for a regulatory pathway to allow AMR diagnostics developers to benefit from incentives based on the public health benefits of their products.An open-access roadmap publication describing the proposed policy.

该网络B2B2B AMRDX汇集了来自大学（替补席），医院（床边），营利性（商业），政府和非营利组织（超越）的各种各样的研究人员，以应对其中一些挑战。我们在人类，动物和环境AMR方面拥有专业知识，来自20个不同的国家。网络目标如下。首先，该网络创建了一个全面的在线AMR Diagnostics开发人员目录（ADDD），以促进该领域的思想交换。其次，该网络扩展了JPIAMR SEQ4AMR虚拟基准测试平台（VBP），以使诊断开发人员可以系统地评估其诊断，并在高质量的基因型（基因组数据）和表型（基因组数据）和表型（抗微生物耐药性数据）上进行评估，并确定其优势和弱点。第三，该网络确定了可以通过考虑使用AMR诊断的公共卫生益处来支持诊断开发和采用的新政策方向。这些事态发展将有助于AMR诊断跨越“死亡谷”并帮助患者。预期的结果：开放的，经过精心策划的在线AMR诊断开发人员目录（ADDD），基于AMR Insights的技术页面，一个开发基因型，表型和元数据的网络的标准的研讨会。 （Raphenya等，2022）一种系统的方法，用于管理，选择和策划黄金标准NGS数据，表型数据和元数据，以及用于VBP的相应细菌分离株。传播，传播和路线图Open-Access公开，以描述VBP内容，描述VBP内容，并描述其格式，并选择持续设置。可能的期刊：微生物基因组学或类似的期刊。一个研讨会，为监管途径提出建议，以使AMR诊断开发人员根据其产品的公共卫生益处从激励中受益。开放访问路线图出版物描述了拟议的政策。