Automated Peptide Synthesiser

自动化肽合成仪

• 批准号: MR/X013545/1
• 负责人: Sylvain Ladame
• 金额: $ 24.41万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX013545%2F1
• 关键词: Automated; Peptide; Synthesiser

Peptides are short chains of amino acids that can be organised in large and complex structures with uniquely desirable chemical and biological properties. For these reasons, peptides or peptide derivatives have been extensively used in biomedical research as probes (to investigate fundamental biological processes in vitro or in cells); as drugs (being main constituents of drugs and vaccines), or as implants with unique (e.g., adhesive) properties. Researchers across departments at Imperial College develop and use peptides with specific applications in all these areas. Example of application include:(1) The development of new tools to help improve the way diseases, such as cancer, are diagnosed and then treated. (2) The development of new materials such as adhesives that can help repair failing hearts, bone tissue matrices. (3) The development of novel devices for drug delivery, or specific applications such as minimising risks during bypass surgery.The requested automated peptide synthesiser, PurePep Chorus, will enable the parallel synthesis of up to six peptides simultaneously. As such It will free up valuable staff time by replacing the laborious and time-consuming procedure of manual peptide synthesis. Importantly it will alleviate the health risks associated with the process of manual peptide synthesis due to the exposure to allergens and toxic chemicals. The non-availability of an in-house state-of-the art peptide synthesiser is a key bottle neck in the progression and expansion of research at Imperial, examples of which are described above. The PurePep Chorus will be housed in the managed Bionanofabrication facility in the Sir Michael Uren Hub at White City and will be accessible to academics across Imperial College as well as external academic and industrial users.

肽是氨基酸的短链，可以在具有独特所需的化学和生物学特性的大型和复杂结构中组织。由于这些原因，肽或肽衍生物已在生物医学研究中广泛使用用作探针（以研究体外或细胞中的基本生物学过程）；作为药物（是药物和疫苗的主要成分），或作为具有独特特性（例如粘合剂）特性的植入物。帝国学院各个部门的研究人员在所有这些领域开发和使用具有特定应用的肽。应用的示例包括：（1）开发新工具，以帮助改善疾病（例如癌症）的方式，然后进行治疗。 （2）开发新材料，例如可以帮助修复骨组织矩阵失败的心脏的粘合剂。 （3）开发新型药物输送设备或旁路手术期间的风险等特定应用。所需的自动肽合成器PurePep合唱将使高达六个肽的平行合成可同时合成。因此，它将通过更换手动肽合成的费力和耗时的程序来释放宝贵的员工时间。重要的是，由于暴露于过敏原和有毒化学物质，它将减轻与手动肽合成过程相关的健康风险。内部最先进的肽合成器的不可利用性是帝国研究中研究和扩展的关键瓶颈，上面描述了其中的示例。 Pure Pep合唱团将安置在怀特城的Michael Uren Hub爵士的托管Bionanofrication设施中，并将在帝国学院以及外部学术和工业用户的学者中获得。