New Capability for Spatial Molecular Imaging at King's College London

伦敦国王学院空间分子成像新能力

• 批准号: MR/X012476/1
• 负责人: Ciro Chiappini
• 金额: $ 33.48万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX012476%2F1
• 关键词: New; Capability; Spatial; Molecular; Imaging

In recent years, advances in technology have provided researchers with the opportunity to map the distribution of many molecules simultaneously within a tissue. CosMx Spatial Molecular Imager is one of the newest generation instruments that can for the first time map the location of thousands of molecules at a time within individual cells in a 3D context.In this proposal, we intend to purchase a CosMx, so that we can use it to enhance our understanding of how individual cells interact with their neighbours and their environment, and how cells organise themselves into tissues and organs. Ultimately, this spatial information will provide insights into biological functions necessary to human life. Our research aims to dig deeper into the study of complex interactions between cells and the way in which their interaction may fail. This will further our knowledge of how humans develop, and how diseases arise and progress. It will help us build better treatments and new therapies, such as those to regenerate lost organ function. We have circulated a survey to research groups within King's College London to gauge the need for this instrument. Based on the survey's results, 50 academics across 19 departments and 3 faculties will use CosMx to explore over 1000 samples and, in turn,advance healthcare research. By acquiring this instrument and setting up the infrastructure to analyse data from CosMx, we will enable an unrivalled body of knowledge. These projects include the development of new methods for medical research, improving understanding of the interaction between cells, developing knowledge for cancer, cardiovascular and neurodegenerative diseases, as well as identifying new drugs and approaches to regenerate organs and restore their original functionality.At King's College London, we have established other technologies that are complementary to CosMx. We plan to establish a new facility which will include CosMx, so researchers will be able to easily access it. We will also promote the capability of this state-of-the-art instrument to researchers at King's College London, and throughout the local area of London and SE of England. Our objective is to maximise the benefits of this instrument for the research community. King's College London is highly supportive of this initiative providing a 20% contribution over the cost of instrument acquisition and substantial support for its long term sustainability. Moreover, this acquisition will promote the potential of uniquely qualified post-doctoral fellows and technical and research technical professionals to develop in their careers.

近年来，技术的进步为研究人员提供了机会，可以在组织中同时绘制许多分子的分布。 COSMX空间分子成像仪是最新的一代工具之一，可以首次在3D环境中一次在单个单元格中一次绘制数千个分子的位置。在此提案中，我们打算购买COSMX，以便我们可以利用它来增强对单个细胞与邻居及其环境相互作用的理解，并将其与他们的环境及其自身的环境相互作用，并将其自身与您的环境相互作用。最终，这些空间信息将提供对人类生活所需的生物学功能的见解。我们的研究旨在深入研究细胞之间复杂相互作用以及它们相互作用可能失败的方式的研究。这将进一步了解我们对人类的发展方式以及疾病的出现和进步方式。它将帮助我们建立更好的治疗方法和新疗法，例如那些再生器官功能损失的疗法。我们已经向伦敦国王学院内的研究小组分发了一项调查，以衡量该乐器的需求。根据调查的结果，在19个部门和3个学院的50家学术界将使用COSMX探索1000多个样本，进而提高医疗保健研究。通过获取该工具并建立基础架构以分析COSMX的数据，我们将实现无与伦比的知识体系。这些项目包括开发医学研究的新方法，提高对细胞之间的相互作用的了解，发展癌症的知识，心血管和神经退行性疾病，以及确定新药和方法以再生器官的再生和恢复其原始功能。在国王学院伦敦，我们已经建立了其他与COSMX互补的技术。我们计划建立一个包括COSMX在内的新设施，以便研究人员可以轻松访问它。我们还将促进伦敦国王学院以及整个伦敦和英国伦敦地区的研究人员，促进这种最先进的工具的能力。我们的目标是最大程度地利用该工具对研究界的好处。伦敦国王学院（King's College London）高度支持这项倡议，在仪器获取成本和对其长期可持续性的大量支持方面提供了20％的贡献。此外，此次收购将促进独特的博士后研究员以及技术和研究技术专业人员在职业生涯中发展的潜力。