ANALYSIS OF MORPHOMETRIC VARIABILITY AN APPLICATION OF PARALLEL PROCESSING

形态变异性分析及其并行处理的应用

• 批准号: 6221070
• 负责人: JOHN C MAZZIOTTA
• 金额: $ 0.13万
• 依托单位: MELLON PITTS CORPORATION (MPC CORP)
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6221070
• 关键词: bacteria; biomedical resource; infection; sexually transmitted diseases; virus

Disease caused by Neisseria gonorrhoeae is a significant world-wide public health problem. A key to the successful management of this disease is defining the attributes which make the gonococcus a human pathogen. The ability of the gonococcus to multiply is dependent upon obtaining growth-essential iron. Withholding iron by vertebrate hosts is a principal mechanism of non-specific immunity against infection. Thus, the expression of a high-affinity iron-acquisition system is a prerequisite for infection. A central component in the process of iron acquisition by gonococci is the periplasmic iron-binding protein, Fbp. To more clearly elucidate the molecular basis of gonococcal iron-acquisition, we intend to study aspects related to Fbp which will specifically define its role in this mechanism and exploit is as a probe to define other molecular participants of the process. An essential component of our studies involves the use of computing facilities which will facilitate (1) the storage and analysis of nucleic acid and protein sequences, (2) database searches for sequences and structural motifs, (3) molecular modeling, and (4) statistical analysis of large amounts of data. In addition, graphical display of results is important for data analysis and presentation.

淋病奈瑟氏菌引起的疾病是重要的 全球公共卫生问题。 成功管理的关键 这种疾病正在定义使淋球菌A的属性 人病原体。 淋球菌繁殖的能力为 取决于获得生长的铁。 扣留铁 脊椎动物宿主是非特异性免疫力的主要机制 反对感染。 因此，高亲和力的表达 铁进取系统是感染的先决条件。 中央 在淋球菌获取铁的过程中的组成部分是 周质铁结合蛋白，FBP。更清楚地阐明 淋球菌铁的分子基础，我们打算研究 与FBP有关的方面，该方面将专门定义其在此中的作用 机理和利用是定义其他分子的探针 该过程的参与者。 我们研究的重要组成部分 涉及使用计算设施，这些设施将有助于（1） 核酸和蛋白质序列的存储和分析，（2） 数据库搜索序列和结构基序，（3）分子 建模和（4）大量数据的统计分析。 在 此外，结果的图形显示对于数据分析很重要 和演示。