OXIDATIVE METABOLIC ENZYMES NADH PEROXIDASE, NADH OXIDASE

氧化代谢酶 NADH 过氧化物酶、NADH 氧化酶

• 批准号: 6119404
• 负责人: Joanne I Yeh
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119404
• 关键词: bacteria; proteins

The enteric facultative anaerobes, such as Enterococcus faecalis, are catalase-negative phenotypes and are deficient in heme biosynthesis. Although they also lack respiratory cytochromes, the S. faecalis utilizes oxygen to enhance growth yields. These organisms rely entirely on substrate-level phosphorylation for ATP synthesis and utilizes novel flavoenzymes as oxidoreductases. An understanding of the structural organization of many of the elements contributing to E. faecalis metabolism and regulation would give a clearer picture of their proliferative mechanism. The roles of these flavin-linked enzymes in enterococcal oxidative metabolism and their contribution to their proliferation may yield insight to novel approaches of limiting infection by these organisms.

肠道疗法厌氧菌，例如肠球菌粪便， 是过氧化氢酶阴性表型，血红素不足 生物合成。 尽管它们也缺乏呼吸细胞色素，但S. 粪便利用氧气来提高生长产量。 这些生物 完全依靠底物级磷酸化进行ATP合成和 利用新型的黄酮酶作为氧化还原酶。 对 许多促成E.的元素的结构组织 粪便代谢和调节将使 它们的增殖机制。 这些黄素连接的角色 肠球菌氧化代谢中的酶及其对 它们的扩散可能会洞悉局限性的新方法 这些生物感染。