The cellular immune response to B.1.1.7 variant COVID-19 deciphered by single cell multi-omics

单细胞多组学破译对 B.1.1.7 变体 COVID-19 的细胞免疫反应

• 批准号: MR/W014556/1
• 负责人: Berthold Gottgens
• 金额: $ 4.75万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW014556%2F1
• 关键词: cellular; immune; response; B.1.1.7; variant; cellular; immune; response; B.1.1.7; variant

Regardless of rapid vaccination programs, the coronavirus SARS-CoV2 is likely to remain a concern for the foreseeable future, because viral pathogens evolve, and acquire mutations that may alter severity of the disease or render current vaccines ineffective. During the 1st wave of coronavirus, we have analysed over 800,000 blood and immune cells from more than 100 patients treated in Cambridge, Newcastle and London. This work provides the largest reference dataset available anywhere to interrogate how blood and immune cells are affected by the infection, and may contribute to fighting it. Given the recent emergence of a more aggressive strain (the so-called UK or Kent variant), there is an urgent need to investigate whether this new variant causes the same changes in blood and immune cells as the original strain. Such information is vital to know whether current therapies need to be amended, and whether there are opportunities to develop new treatments. We propose to answer these important questions by studying 30 patients of the current wave, where the majority are infected with the new variant. Because of time sensitivity, our results will be made available to the wider scientific community as soon as is practicable.

不管快速疫苗接种计划如何，冠状病毒SARS-COV2可能仍然是可预见的未来的关注点，因为病毒病原体会发展并获得可能改变疾病严重程度或使当前疫苗无效的突变。在第一波冠状病毒中，我们分析了在剑桥，纽卡斯尔和伦敦接受100多名患者的800,000多名血液和免疫细胞。这项工作为任何地方提供了最大的参考数据集，以询问血液和免疫细胞如何受感染的影响，并可能有助于对抗它。鉴于最近出现了更具侵略性的菌株（所谓的英国或肯特变体），因此迫切需要研究这种新变体是否会导致血液和免疫细胞与原始菌株相同的变化。这样的信息对于知道是否需要修改当前的疗法以及是否有开发新疗法的机会至关重要。我们建议通过研究30名当前波的患者来回答这些重要问题，其中大多数人都感染了新变体。由于时间的敏感性，我们的结果将在可行的情况下立即提供给更广泛的科学界。