IN VITRO ASSESSMENT OF LIPID PEROXIDATION IN CARDIAC PATIENTS

心脏病患者脂质过氧化的体外评估

• 批准号: 6265176
• 负责人: SOTIRIOS TSIMIKAS
• 金额: $ 1.15万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265176
• 关键词: angina pectoris; antibody specificity; biomarker; blood chemistry; blood vessel prosthesis; clinical research; coronary artery; diagnosis design /evaluation; heart disorder diagnosis; heart revascularization; heart transplantation; human subject; lipids; myocardial infarction; oxidation reduction reaction; peroxidation; postoperative state; preoperative state; transplant rejection

Assess the presence of lipid peroxidation in the blood in various cardiac disorders such as stable angina, unstable angina, myocardial infarction, pre/post angioplasty and/or coronary stent placement, or cardiac transplantation/rejection. Assays for presence of oxidation-specific antibodies will be utilized to assess the presence or absence of antibodies in the blood of cardiac patients as a marker of long-standing lipid peroxidation.

评估各种心脏疾病中血液中脂质过氧化的存在，例如稳定的心绞痛，不稳定的心绞痛，心肌梗塞，血管前/后血管成形术和/或冠状动脉支架位置，或心脏移植/排斥。 将利用存在氧化特异性抗体的测定法评估心脏患者血液中抗体的存在或不存在，作为长期脂质过氧化的标志。