MACROMOLECULAR & METABOLITE MODELS FOR CELL BIOLOGY: CD ROM TEACHING TOOL

高分子

• 批准号: 6280162
• 负责人: TOM DALLMAN
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6280162
• 关键词: biological products; biomedical resource; computers; education; plants

I am creating a CD-ROM using yeast as a model system to contextualize the subject of cell biology (including biochemistry, genetics and molecular biology). A historical time-line illustrating important biological and chemical discoveries and a section tracing the yeast industry (from farms to sugar refineries to bakeries, breweries, wineries and distilleries) are included. I used MidasPlus Software to render an cohesive graphics library of polypeptide and nucleic acid images from the PDB database. I also generated a large library of metabolic intermediates in PDB format using LEAP (part of the AMBER molecular dynamics simulation software) and rendered the output in the same manner as the PDB database files. These components provide a visual key to biochemistry and regulation that will serve as a teaching aid, especially for those not predisposed to biology. All the graphics are keyed into information from the Brookhaven Data Bank and the Saccharomyces genome database which makes these and other resources more available to the average student . Over the past year, I have concentrated on the historical aspect by making and rendering molecular models that illustrate how our modern concepts of chemistry and crystallography arose. Experiments performed by the pneumatic chemists of the 1700's, ie. Black, Cavendish, Priestley, Lavoissier illustrated with today's MidasPlus graphic output not only place important concepts relating photosynthesis, respiration, combustion and fermentation in a tangible and intriguing setting they relate simple molecular models with the complicated models found in the PDB database. Demystification of the eye catching images produced by today's science is necessary to help students think critically. I also made an animation of the yeast life cycle that will serve as a background for the MidasPlus graphic output I generated along with detailed animation's of DNA replication, signal transduction, and oxidative phosphorylation.

我正在使用酵母作为模型系统创建一个 CD-ROM 将细胞生物学的主题（包括生物化学， 遗传学和分子生物学）。 历史时间线说明 重要的生物和化学发现以及剖面追踪 酵母工业（从农场到糖精炼厂再到面包店， 啤酒厂、酿酒厂和酿酒厂）都包括在内。 我用过MidasPlus 用于渲染多肽和内聚图形库的软件 来自 PDB 数据库的核酸图像。 我还生成了一个大的 使用 LEAP 的 PDB 格式的代谢中间体库（部分 AMBER 分子动力学模拟软件）并渲染了 以与 PDB 数据库文件相同的方式输出。 这些组件 为生物化学和调节提供可视化的关键，这将作为 一种教学辅助工具，特别是对于那些不喜欢生物学的人来说。 全部 这些图形被输入布鲁克海文数据库的信息中 以及酿酒酵母基因组数据库，它使这些和其他 普通学生可以获得更多资源。 在过去的一年里， 我通过制作和渲染专注于历史方面 说明我们现代化学概念的分子模型 并出现了晶体学。 气动实验 1700年代的化学家，即。 布莱克、卡文迪什、普里斯特利、拉瓦锡 说明了今天的 MidasPlus 图形输出不仅发生在 与光合作用、呼吸作用、燃烧有关的重要概念 以及在他们所涉及的有形且有趣的环境中发酵 简单的分子模型与 PDB 中的复杂模型 数据库。 揭开引人注目的图像的神秘面纱 今天的科学有必要帮助学生进行批判性思考。 我 还制作了酵母生命周期的动画，该动画将作为 我生成的 MidasPlus 图形输出的背景 DNA 复制、信号转导的详细动画 氧化磷酸化。