SPUTUM CYTOLOGY & URINARY BOMBESIN LIKE PEPTIDE LEVELS

痰细胞学检查

• 批准号: 6263980
• 负责人: Cecile S Rose
• 金额: $ 3.22万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263980
• 关键词: asbestos; biomarker; bombesin like peptide; cancer risk; cellular oncology; clinical research; cytodiagnosis; human subject; lung neoplasms; occupational hazard; sputum; urinalysis

The major goal of this proposal is to investigate biomarkers of lung cancer risk in a population with occupational exposure to asbestos, a known pulmonary carcinogen. Sputum cytology and urinary bombesin-like peptide (BLP) levels are the biomarker outcome variables. We have completed data collection on 220 study participants meeting eligibility criteria of age > 40 years and at least 15 years of asbestos exposure. We have found high prevalence rates of radiographic asbestos-related diseases (16% asbestosis and 31% pleural abnormalities); high rates of airflow limitation (51% with FEV1 < 70% predicted); and high rates of sputum cellular atypia (28% moderate atypia, 49% mild atypia, 4% squamous metaplasia, 19% normal, and 10% unsatisfactory specimens). These data demonstrate our ability to recruit individuals at high risk for lung cancer, show that sputum cytologic abnormalities are frequent in asbestos-exposed construction trades workers, and lay the foundation for a chemoprevention trial.

该提案的主要目的是研究肺癌风险的生物标志物，在职业接触石棉的人群中，这是一种已知的肺癌。痰细胞学和尿液样肽（BLP）水平是生物标志物结果变量。我们已经完成了220名研究参与者的数据收集，符合40岁的资格标准和至少15年的石棉暴露。我们发现，放射石棉相关疾病的高患病率（16％的石棉和31％胸膜异常）；高气流限制率（51％，FEV1 <70％预测）；痰细胞异型（28％的异型，49％轻度异型，4％鳞状化生，19％正常和10％的标本不令人满意的标本）和高痰率率高。这些数据表明我们有能力招募肺癌高风险的个体，表明在石棉暴露的建筑业工人中经常存在痰细胞学异常，并为化学预防试验奠定了基础。