ROLE OF ADHESION MOLECULES IN RECRUITMENT OF IMMUNE CELLS TO SKIN

粘附分子在免疫细胞募集到皮肤中的作用

• 批准号: 6123761
• 负责人: S T HWANG
• 金额: --
• 依托单位: DIVISION OF CLINICAL SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6123761
• 关键词: Langerhans' cell; cell adhesion molecules; chemoattractants; intracellular transport; laboratory mouse; leukocytes; melanocyte; selectins; skin

"The Chronic Persistent Dermatitis Mutation (cpdm) in mice is a spontaneous, autosomal recessive mutation that is characterized by the development of thickened, scaly skin similar to that observed in the human inflammatory skin condition called psoriasis. Histologically, the skin of these animals have many leukocytes in the skin including the presence of neutrophils in the epidermis. L-selectin is an adhesion molecule found on all classes of leukocytes and is thought to be important in mediating the initial attachment of leukocytes to vascular endothelium. Preliminary staining of skin sections from these mice showed easily detectable amounts of a ligand for L-selectin on the dermal endothelium of these animals. To date, this is the only genetic animal model of dermal vascular expression of L-selectin ligands in an inflammatory skin condition. It has been shown that L-selectin ligands are expressed in a variety of human inflammatory skin conditions including psoriasis. Because of this, we plan to use this model in a variety of ways to better understand the role of L-selectin and its ligands in the recruitment of leukocytes to the skin. Recent data from collaborators indicate the predominant cells in the dermal infiltrate are eosinophils. Because of the difficulties involved in studing eosinophil skin migration in mice, we have placed little emphasis on this project in the past year."

“慢性持续性皮炎突变（cpdm） 在小鼠中是一种自发的常染色体隐性突变 其特征是皮肤增厚、鳞状，类似于 在人类炎症性皮肤病中观察到的 银屑病。从组织学上看，这些动物的皮肤有许多 皮肤中的白细胞，包括中性粒细胞的存在 表皮。 L-选择素是一种粘附分子，存在于所有类别的 白细胞，被认为在介导初始 白细胞附着于血管内皮。初步的 这些小鼠皮肤切片的染色显示很容易检测到 真皮内皮上 L-选择素配体的量 这些动物。迄今为止，这是唯一的遗传动物模型 L-选择素配体在炎症中的真皮血管表达 皮肤状况。研究表明，L-选择素配体 在多种人类炎症性皮肤病中表达 包括牛皮癣。因此，我们计划在 通过多种方式更好地了解 L-选择素及其作用 将白细胞募集到皮肤的配体。近期数据 合作者指出真皮中的主要细胞 浸润者为嗜酸性粒细胞。由于其中涉及的困难 研究小鼠嗜酸性粒细胞皮肤迁移，我们放置了很少的 去年对这个项目的重视。”