INTERACTION OF HORMONES AND PHYSICAL STRESS ON BONE MASS

激素和身体压力对骨量的相互作用

• 批准号: 3105187
• 负责人: Carl T. Brighton
• 金额: $ 88.29万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105187
• 关键词: calcitonin; hormone regulation /control mechanism; injury /disease stressor; osteoporosis; physiologic bone resorption

The proposed specialized Center of Research in Osteoporosis is a broadly based multidisciplinary, shared facility research program that has as its central theme the improved understanding of the inter-relationship of hormones (estrogen, calcitonin) and physical stress (electrical and mechanical) in preserving and restoring bone mass. Loss of bone mass is a complex phenomenon involving hormonal changes, inadequate diet, lack of mechanical stimuli, and perhaps even lack of appropriate endogenous electrical potentials arising from bone itself. It seems reasonable to assume that a complete understanding of the basic underlying cause of osteoporosis will not be gained until the inter-relationship of the various hormonal changes and mechanical and electrical effects of estrogen and/or calcitonin deficiency on bone mass and relate this to the mechanical and electrical properties of bone at the molecular, cellular, osteonal, and whole bone levels. In each of the proposed projects the strategy is to try and relate hormonal, mechanical, or electrical effects, singularly or in combination, to osteoporosis. The four core facilities relate to this strategy in that they each provide two or more of the projects with mechanical testing of bone specimens (Mechanical Testing Core), histomorphometry of bone specimens (Histomorphometry Core), computation and data analysis (Computation Core), and administration of personnel, facilities, supplies, and services (Administration Core).

拟议的骨质疏松症专业研究中心是一个 基础广泛的多学科、共享设施研究计划 其中心主题是加深对 激素（雌激素、降钙素）与身体的相互关系 保存和恢复骨骼时的应力（电应力和机械应力） 大量的。 骨质流失是一个复杂的现象，涉及 荷尔蒙变化、饮食不足、缺乏机械刺激， 甚至可能缺乏适当的内源性电 骨骼本身产生的潜力。 假设似乎是合理的 全面了解基本的根本原因 只有当骨质疏松症的相互关系得到改善时，才会出现骨质疏松症。 各种荷尔蒙变化以及机械和电气效应 雌激素和/或降钙素缺乏对骨量的影响及其相关性 这与骨骼的机械和电气特性有关 分子、细胞、骨和全骨水平。 在每个 拟议项目的策略是尝试将荷尔蒙联系起来， 机械或电效应，单独或组合，以 骨质疏松症。 与这一战略相关的四个核心设施 他们每个人都提供两个或多个项目 骨样本的机械测试（机械测试核心）， 骨标本的组织形态计量学（组织形态计量学核心）， 计算和数据分析（计算核心），以及 人员、设施、用品和服务的管理 （管理核心）。