PACEMAKER CURRENT AND ITS MODULATION IN YOUNG AND ADULT VENTRICLE

年轻和成人心室中的起搏器电流及其调节

• 批准号: 6241742
• 负责人: IRA S COHEN
• 金额: $ 31.81万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6241742
• 关键词: G protein; age difference; alpha adrenergic agent; arrhythmia; cardiotonic agents; computer simulation; dogs; endocardium; growth /development; heart Purkinje's fiber; heart contraction; heart electrical activity; heart pacemaker tissue; heart pharmacology; heart rate; heart rhythm; laboratory rabbit; muscarinic receptor; neuropeptide Y; newborn animals; propranolol; sodium channel; vasoactive intestinal peptide; voltage /patch clamp

SUBPROJECT ABSTRACT NOT AVAILABLE. PARENT ABSTRACT: Our program focuses on the determinants of cardiac rhythm and arrhythmias in the young. Our hypothesis is that the expression of electrophysiologic function in the young is influenced by the autonomic nervous system and the electrophysiologic properties of the heart in ways that differ importantly from the adult, and that require our in depth understanding if we are to prevent and treat disorders of the heart beat. Hence, we intend to study the neonatal, young and adult animal. Our approach is multifaceted in that electrophysiological, biophysical, biochemical, pharmacological, and cell culture techniques are used in studies of intact animals, isolated tissues, single cells and subcellular components. Although arrhythmogenesis in general can be thought of as encompassing abnormalities of impulse initiation and/or conduction, our intent in this five-year period is to concentrate on impulse initiation and its relationship to repolarization. The projects in the Program stress the study of electrophysiologic properties of intact animals and isolated tissues, ionic determinants of impulse initiation studied in the above models (Project A) and in single myocytes and cultured cells, and receptor-effector coupling. The Cores provide support services, and cell disaggregation and tissue culture. Although our overall approach includes the adult as a major reference population, the most intensive area of investigation is centered on the neonate and young. The significance of these studies is that they are geared to the young age group as a unique population in which rhythm and arrhythmias truly differ in their genesis and autonomic modulation from the adult. Using the information obtained we not only shall improve our understanding of the mechanisms responsible for normal rhythm and arrhythmias but can design and seek new means for the prevention and treatment of arrhythmias.

subproject摘要不可用。 父摘要： 我们的计划着重于心律和心律不齐的决定因素 在年轻人。 我们的假设是 年轻的电生理功能受自主神经的影响 神经系统和心脏的电生理特性以方式 这与成人重要的不同，这需要我们深入 了解我们是否要预防和治疗心脏跳动的疾病。 因此，我们打算研究新生儿，年轻动物和成人动物。 我们的 方法是多方面的，在该电生理学，生物物理， 生化，药理学和细胞培养技术用于 对完整动物，孤立组织，单细胞和亚细胞的研究 成分。 尽管心律失常通常可以被认为是 包括脉冲开始和/或传导的异常，我们 在这个五年期间的意图是集中精力脉冲开始 及其与复极化的关系。 计划中的项目 强调完整动物的电生理特性和 分离的组织，在研究中研究的脉冲开始的离子决定因素 以上模型（项目A），单个肌细胞和培养细胞，以及 受体效应耦合。 核心提供支持服务，细胞分解和组织 文化。 尽管我们的整体方法包括成年人 参考人群，调查最密集的领域是 以新生儿和年轻为中心。 这些研究的意义是 他们适合年龄段作为独特的人口 节奏和心律不齐在其起源和自主神经上确实有所不同 成人的调节。 使用获得的信息，我们不仅 应提高我们对负责正常机制的理解 节奏和心律不齐，但可以设计和寻求新的手段 心律不齐的预防和治疗。