MOLECULAR AND GENETIC APPROACHES TO CHILDHOOD DISEASES

儿童疾病的分子和遗传学方法

• 批准号: 2838818
• 负责人: HARVEY J COHEN
• 金额: $ 35万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-15 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2838818
• 关键词: biomedical facility; cell sorting; computer assisted sequence analysis; developmental genetics; health science research; immunology; molecular pathology; nucleic acid chemical synthesis; nucleic acid sequence; pediatric neoplasm /cancer; pediatrics; peptide chemical synthesis; perinatal; postnatal growth disorder; protein sequence; transplantation

This application requests support for a Child Health Research Center (CHRC) at Stanford University School of Medicine. The scientific mission of the proposed CHRC is to bring together the junior and senior faculty of the Department of Pediatrics and faculty members from other departments who have related interests, in order to facilitate the application of cellular, molecular and genetic methods to unresolved problems in child health. Leadership of the program will be provided by Dr. Harvey Cohen, the chairman of the Department of Pediatrics, and Dr. Ann Arvin, Associate Chair for Academic Affairs. The primary objective of the CHRC is to support the research of younger investigators who have clinical training in pediatrics in order to enhance their opportunities to investigate basic mechanisms of childhood diseases. Our premise is that this new generation of pediatric investigators has an essential contribution to make to the future of pediatric practice. With the guidance of their senior colleagues, these investigators must have appropriate early career experiences to make the "bench to bedside" concept into a reality for children. This objective will be addressed through the creation of three primary research affinity groups, to consist of the Program in Immunology and Transplantation Biology, the Program in Genetics and Cancer Biology and the Program in Developmental Biology. Senior, mid-level and junior faculty will participate in these programs according to their individual research interests. Junior faculty from each program will be eligible to compete for New Project Development Awards designed to help them achieve necessary expertise in basic scientific research. The second objective of the CHRC is to create a Pediatric Core Laboratory. CHRC funds will be used to administer a functional, interactive technical support facility with appropriate educational programs and to buy essential equipment for common use. This facility will be designed to serve the needs of department faculty at all stages of career development, acting as a resource for education about new scientific technology and its applications to biomedical research and as a mechanism for joint purchase and shared use of the very costly equipment needed for this work. This request for CHRC support is being made at a unique time in the history of our Department of Pediatrics and is based on a major new institutional commitment to the growth of basic research programs related to child health. Resources have been provided that will permit recruitment of at least ten laboratory-based junior faculty during the five year period that coincides with CHRC support and extensive, newly remodelled laboratory space has been assigned to pediatrics. The academic programs of the Department of Pediatrics are associated with the new Lucile Salter Packard Children's Hospital, a resource which makes our environment ideal for the direct transfer of advancements in pediatric research to improving the health of children.

该申请要求支持儿童健康研究中心 （CHRC）在斯坦福大学医学院。 科学任务 拟议的CHRC是将 其他部门的儿科和教职员工 有相关利益的人，以促进 儿童未解决问题的细胞，分子和遗传学方法 健康。 该计划的领导将由Harvey Cohen博士提供 儿科系主任和助理安·阿文博士 学术事务主席。 CHRC的主要目的是 支持接受临床培训的年轻研究者的研究 在儿科中，以增强他们调查基本的机会 儿童疾病的机制。 我们的前提是新一代 小儿研究人员对 小儿实践的未来。 在他们的大四的指导下 同事，这些调查人员必须具有适当的早期职业 将“长椅”概念变成现实的经验 孩子们。 这个目标将通过创建三个 主要研究亲和力小组，包括免疫学计划 和移植生物学，遗传学和癌症生物学方案 以及发展生物学的计划。 高级，中级和初中 教师将根据其个人参加这些计划 研究兴趣。 每个计划的初级教师都有资格 竞争旨在帮助他们实现的新项目开发奖 基础科学研究的必要专业知识。 第二个目标 CHRC将创建一个儿科核心实验室。 CHRC资金将是 用于管理功能性的交互式技术支持设施 通过适当的教育计划，并为 常用。 该设施将旨在满足 在职业发展的各个阶段，部门教师 有关新科学技术及其的教育资源 应用于生物医学研究和作为联合购买的机制 并共同使用这项工作所需的非常昂贵的设备。 这 在历史上的独特时刻，正在向CHRC支持的要求 我们的儿科部，基于一个主要的新机构 致力于与儿童有关的基础研究计划的增长 健康。 已经提供了将允许AT招募的资源 在五年期间，至少十个基于实验室的初级教师 与CHR的支持和广泛的新型实验室相吻合 空间已分配给儿科。 学术课程 儿科系与新的Lucile Salter Packard有关 儿童医院，这是一种使我们的环境理想的资源 在儿科研究中直接转移进步以改善 儿童健康。