Inhalation Toxicity Studies of alpha,beta-Unsaturated Ketones

α,β-不饱和酮的吸入毒性研究

• 批准号: 6106643
• 负责人: DANIEL MORGAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6106643
• 关键词: environmental toxicology; inhalation drug administration; ketones; saturated /unsaturated bonds; toxicant screening

Methylvinyl ketone (MVK), ethylvinyl ketone (EVK), and 2-cyclohexene-1-one (CHX) were nominated and selected for study by the NTP as part of a class study on alpha,beta-unsaturated ketones. MVK is a representative noncyclic member of the major class of straight-chain aliphatic alpha,beta-unsaturated ketones. EVK is a secondary conjugated carbonyl compound from the subclass of aliphatic alpha,beta-unsaturated ketones. CHX is a prototype of the cyclic alpha,beta-unsaturated ketones. Prechronic Inhalation studies of these ketones are being conducted to characterize and compare the relative toxicities and also to facilitate the design of chronic inhalation studies of these chemicals. Following completion of prechronic studies, mechanistic studies will be considered, and if needed, two-year bioassays will be performed through NTP contracts. This chemical class study will allow more accurate prediction of the potential toxicity and carcinogenicity of other untested alpha,beta-unsaturated ketones. Prechronic (14- and 90-day) studies of CHX and MVK have been completed, and data are being evaluated. Methods are being developed for generation and monitoring of EVK. EVK will be studied using the same designs used to study CHX and MVK.

甲基乙烯基酮(MVK)、乙基乙烯基酮 (EVK) 和 2-环己烯-1-酮 (CHX) 被提名并 作为课堂研究的一部分被 NTP 选择进行研究 α，β-不饱和酮。 MVK是具有代表性的非循环 直链脂肪族主要类别的成员 α，β-不饱和酮。 EVK 是二次共轭 脂肪族亚类的羰基化合物 α，β-不饱和酮。 CHX是循环的原型 α，β-不饱和酮。慢性前期吸入研究 正在对这些酮进行表征和比较 相对毒性，也有利于慢性病的设计 这些化学物质的吸入研究。完成后 将考虑慢性前期研究、机制研究，并且如果 根据需要，将通过 NTP 进行为期两年的生物测定 合同。该化学课程研究将更加准确 预测其他物质的潜在毒性和致癌性 未经测试的α，β-不饱和酮。慢性前期（14岁和 90天）CHX和MVK的研究已经完成，数据 正在评估中。正在开发生成方法 和 EVK 监控。 EVK 将使用相同的方法进行研究 用于研究 CHX 和 MVK 的设计。