Utilizing gametocyte immunity to reduce malaria transmission

利用配子体免疫减少疟疾传播

• 批准号: MR/T016272/1
• 负责人: Matthias Marti
• 金额: $ 278.2万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT016272%2F1
• 关键词: Utilizing; gametocyte; immunity; reduce; malaria

The continuing success of the current malaria elimination campaign requires novel tools to efficiently block human infection and subsequent transmission of the parasite to mosquitoes. Current transmission blocking strategies target the development of the parasite in the mosquito stage, requiring complicated mosquito feeding readouts to measure efficacy. We recently identified the bone marrow as the major site of transmission stage development during infection. Based on this finding we hypothesized that the underlying host parasite interactions could be exploited to block parasite transmission. Indeed our preliminary studies demonstrate natural immune responses against parasite surface antigens and their functionality in terms of immune clearance. Here we utilize this new understanding to systematically define the immunity targeting malaria transmission with the ultimate goal of prioritizing a set of novel transmission blocking vaccine candidates.

当前疟疾消除运动的持续成功需要新颖的工具，以有效地阻止人类感染并随后将寄生虫传播到蚊子。当前的传输阻止策略针对蚊子阶段的寄生虫的发展，需要复杂的蚊子进食读数以测量功效。我们最近将骨髓确定为感染过程中传输阶段发育的主要部位。根据这一发现，我们假设可以利用潜在的宿主寄生虫相互作用来阻止寄生虫传播。实际上，我们的初步研究表明，对寄生虫表面抗原的自然免疫反应及其在免疫清除方面的功能。在这里，我们利用这种新的理解来系统地定义靶向疟疾传播的免疫力，其最终目标是优先考虑一组新型的传输阻断疫苗候选物。

项目成果

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections.

• DOI: 10.3389/fimmu.2022.930956
• 发表时间: 2022
• 期刊: FRONTIERS IN IMMUNOLOGY
• 影响因子: 7.3
• 作者: de Jong, Roos M.;Alkema, Manon;Oulton, Tate;Dumont, Elin;Teelen, Karina;Nakajima, Rie;de Assis, Rafael Ramiro;Press, Kathleen W. Dantzler;Ngotho, Priscilla;Tetteh, Kevin K. A.;Felgner, Phil;Marti, Matthias;Collins, Katharine A.;Drakeley, Chris;Bousema, Teun;Stone, Will J. R.
• 通讯作者: Stone, Will J. R.

Plasmodium falciparum serology: A comparison of two protein production methods for analysis of antibody responses by protein microarray.

• DOI: 10.1371/journal.pone.0273106
• 发表时间: 2022
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Oulton, Tate;Obiero, Joshua;Rodriguez, Isabel;Ssewanyana, Isaac;Dabbs, Rebecca A.;Bachman, Christine M.;Greenhouse, Bryan;Drakeley, Chris;Felgner, Phil L.;Stone, Will;Tetteh, Kevin K. A.
• 通讯作者: Tetteh, Kevin K. A.