CORE--LABORATORY

核心--实验室

• 批准号: 6272805
• 负责人: Y M BHATNAGER
• 金额: $ 9.37万
• 依托单位: UNIVERSITY OF SOUTH ALABAMA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-24 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6272805
• 关键词: biomedical facility; blood banks; blood chemistry; blood tests; human subject; sickle cell anemia

(Adapted from the Applicant's Abstract) There are several basic, clinical and developmental research projects in the Comprehensive Sickle Cell Center of the University of South Alabama. The existence of a core laboratory has been beneficial to these projects. The investigators proposal continued funding of the core laboratory within the USA Comprehensive Sickle Cell Center. A major objective of the laboratory is to act as the liaison between the project investigators and clinical coordinator of the Administrative Core to obtain blood and other biological samples. The investigators will also provide services which are common to several research projects, and also assist in the clinical trial of drug(s) for sickle cell subjects. Following specific aims are proposed: (1) to coordinate requests and distribution of blood samples to research investigators; (2) to provide hematological, microscopic, nutritional, biochemical and molecular data on sickle cell subjects providing blood samples; (3) to maintain a multi-user, multi-purpose, equipment room for basic and clinical investigators; (4) to provide for long-term storage of plasma and other blood products for future use; (5) to ensure compliance of research and clinical laboratories within the Center with the regulations and procedures for the use of biohazardous substances; and, (6) to assist in the clinical trial of N-cetyl cysteine for sickle cell disease by providing required hematologic, microscopic, nutritional, biochemical and/or molecular data on the subject population.

（改编自申请人的摘要）有几个基本的临床 和综合镰状细胞中的发展研究项目 南阿拉巴马大学中心。核心的存在 实验室对这些项目有益。调查人员 提案继续为美国境内的核心实验室提供资金 全面的镰状细胞中心。实验室的主要目标是 充当项目调查人员与临床之间的联络 行政核心的协调员获得血液和其他 生物样品。调查人员还将提供服务 几个研究项目共有，也有助于临床试验 镰状细胞受试者的药物。提出了以下特定目标： （1）协调血液样本的请求和分布进行研究 调查人员； （2）提供血液学，微观，营养， 提供血液的镰状细胞受试者的生化和分子数据 样品； （3）维护多用户多功能的设备室 基本和临床研究人员； （4）提供长期存储 血浆和其他血液产品供将来使用； （5）确保合规性 中心内的研究和临床实验室 使用生化物质的法规和程序；和， （6）协助镰状细胞的N-乙酰半胱氨酸的临床试验 通过提供所需的血液学，微观，营养， 对受试者人群的生化和/或分子数据。