AUDITORY SYSTEM EXCITOXIC TRAUMA--EFFERENT PROTECTION

听觉系统兴奋性损伤--有效保护

• 批准号: 6174764
• 负责人: COLLEEN G. LE PRELL
• 金额: $ 3.75万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6174764
• 关键词: Animalia; afferent nerve; auditory stimulus; brain stem; cochlea; dendrites; efferent nerve; electrophysiology; excitatory aminoacid; experimental brain lesion; insect poison; neurophysiology; neurotoxins; neurotransmitter metabolism; noise pollution; perfusion; trauma

The proposed research investigates the role of the efferent system in protecting the eight nerve. Noise, ischemia, and excitatory neurotransmitter-infusion result in similar pathophysiological processes. The efferent system provides protection against at least two of these traumatic insults. In Specific Aim 1, we will test the hypothesis that lateral efferent pathways mediate sound-induced trauma in guinea pigs. We will lesion the lateral superior olive, the origin of lateral efferent fibers, then expose subjects to loud sounds. Lesioned subjects should show more sound-induced damage. Sound-induced functional deficits will also be assessed during cochlear perfusion with lateral efferent neurotransmitters. Perfusion of these neurotransmitters should reduce deficits. In Specific Aim 2, we will test the hypothesis that activation of the efferent system with non-=traumatic acoustic stimulation results in protection against excitatory neurotransmitter-induced trauma. Protective mechanisms will be specifically linked to the efferent pathways when we conduct efferent lesions, and infuse lateral efferent neurotransmitters. Understanding protection by the efferent system may lead to the identification of methods for protecting the auditory system. If we can identify protection mechanisms at a molecular level, we may be able to up- regulate or apply exogenous factors in clinical settings to provide protection to those know they will be exposed to potentially damaging stimulation. Similar treatment could be provided for those likely to undergo periods of transient ischemia during surgical procedures involving the eighth nerve.

拟议的研究调查了传出系统在 保护八神经。噪音，缺血和兴奋性 神经递质灌注会导致类似的病理生理过程。 传出系统为至少两个提供了保护 创伤性侮辱。在特定目标1中，我们将检验以下假设。 侧向传出途径介导了豚鼠中声引起的创伤。我们 会病变侧向上橄榄，侧向发出的起源 纤维，然后暴露于大声的声音。病变的受试者应显示 更多声音引起的伤害。声音引起的功能缺陷也将是 在人工耳蜗灌注期间和横向出现 神经递质。这些神经递质的灌注应减少 缺陷。在特定目标2中，我们将测试激活的假设 具有非=创伤性声学刺激的传出系统导致 防止兴奋性神经递质引起的创伤。保护的 当我们 进行发出的病变，并注入侧向传出神经递质。 了解传出系统的保护可能会导致 识别保护听觉系统的方法。如果可以的话 确定分子水平的保护机制，我们可能能够上升 在临床环境中调节或应用外源性因素以提供 对那些知道他们将受到潜在破坏的人的保护 刺激。可以为可能的人提供类似的待遇 在涉及的手术过程中接受短暂性缺血时期 第八神经。

项目成果

Chronic excitotoxicity in the guinea pig cochlea induces temporary functional deficits without disrupting otoacoustic emissions.

• DOI: 10.1121/1.1772395
• 发表时间: 2004-08
• 期刊: The Journal of the Acoustical Society of America
• 作者: C. L. Le Prell;M. Yagi;K. Kawamoto;L. Beyer;Graham Atkin;Y. Raphael;D. Dolan;S. Bledsoe;D. Moody

Electromotile hearing: acoustic tones mask psychophysical response to high-frequency electrical stimulation of intact guinea pig cochleae.

• DOI: 10.1121/1.2359238
• 发表时间: 2006-12
• 期刊: The Journal of the Acoustical Society of America
• 作者: C. L. Le Prell;K. Kawamoto;Y. Raphael;D. Dolan

Factors influencing the salience of temporal cues in the discrimination of synthetic Japanese monkey (Macaca fuscata) coo calls.

影响日本猴（Macaca fuscata）咕咕声辨别中时间线索显着性的因素。

• DOI: 10.1037//0097-7403.26.3.261
• 发表时间: 2000
• 期刊: Journal of experimental psychology. Animal behavior processes.
• 作者: LePrell,CG;Moody,DB
• 通讯作者: Moody,DB

Detection thresholds for intensity increments in a single harmonic of synthetic Japanese macaque (Macaca fuscata) monkey coo calls.

合成日本猕猴（Macaca fuscata）咕咕叫声的单一谐波强度增量的检测阈值。

• DOI: 10.1037/0735-7036.116.3.253
• 发表时间: 2002
• 期刊: Journal of comparative psychology (Washington, D.C. : 1983)
• 作者: LePrell,ColleenG;Moody,DavidB
• 通讯作者: Moody,DavidB