PATTERN FORMATION IN CHICK MIDBRAIN DEVELOPMENT

雏鸡中脑发育中的模式形成

• 批准号: 6149347
• 负责人: Clifton W. Ragsdale
• 金额: $ 2.5万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6149347
• 关键词: brain; cell migration; chick embryo; developmental neurobiology; gene expression; histochemistry /cytochemistry; neuroanatomy; nonmammalian vertebrate embryology

The PI has found that the ventral midbrain has a transient organization into regularly spaced wedges of tissue distinguished by morphology and histochemistry. The wedges can even be visualized from the ventricular surface as a series of ridges and grooves. The pattern is remarkably similar to the rhombomeres of the hindbrain and they bear a number of anatomical markers that make them essentially as interesting for long term studies. The PI has called these structures midbrain arcs. He hypothesizes logically that these zones of tissue may constitute an early patterning mechanism for organizing neurons and their nuclei with differing neuronal fates as well as the axon projection patterns that arise from and connect with the arcs. He proposes a number of straightforward although technically difficult goals with which to study these various questions.

PI发现腹中脑有一个短暂的组织 通过形态学和 组织化学。 甚至可以从心室​​可视化楔子 表面作为一系列脊和凹槽。 模式非常 类似于后脑的菱形，它们有很多 解剖标记使它们本质上很有趣 术语研究。 PI称这些结构中脑弧。 他 从逻辑上讲，这些组织的这些区域可能构成 与 不同的神经元命运以及轴突投影模式 来自弧并与弧线连接。 他提出了许多 直接学习的直接学习目标 这些各种问题。