NEW METHACRYLIC SILOXANE RESIN BASED SOFT DENTURE LINERS

新型甲基丙烯酸硅氧烷树脂软义齿衬垫

• 批准号: 6176702
• 负责人: JUEY H. LAI
• 金额: $ 28.55万
• 依托单位: LAI LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6176702
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; chemical synthesis; clinical research; composite resins; dental materials; dentures; human subject; polymethacrylate; silicon compounds; technology /technique development

The long-term objectives of this research is to develop improved permanent soft denture lining materials suitable for clinical applications. In Phase I, the physical properties of the new materials were studied as functions of material formulations. Hardness, elongation, tensile strength, tear strength, bonding strength to denture base polymers, water sorption and solubility, the leaching of monomers from the cured specimen, the capability of the new materials to inhibit the growth of Candida albicans, and the polishability of the cured materials were investigated. In Phase II, the optimization of the material formulation and processing methods will be further investigated. Both clinical prosthesis fabrication processes and polishing techniques for the new lining materials will be developed. Clinical prostheses will be fabricated using the nearly optimized materials and processes, and clinical serviceability of the new lining materials will be evaluated and compared with the control Molloplast-B. PROPOSED COMMERCIAL APPLICATIONS: Potential commercial applications of the research is the development of improved soft denture lining material which have permanent resiliency, good bonding to the denture base polymer, low water sorption and solubility, and are suitable for clinical applications.

这项研究的长期目标是开发适合临床应用的永久性软义齿衬里材料。在第一阶段，研究了新材料的物理特性作为材料制剂的功能。硬度，伸长，拉伸强度，撕裂强度，对义齿碱基聚合物的粘结强度，吸水和溶解度，单体从固化的样品中浸出，新材料抑制念珠菌念珠菌的生长的能力以及固化材料的抛光性的能力。在第二阶段，将进一步研究材料配方和加工方法的优化。将开发新衬里材料的临床假体制造过程和抛光技术。将使用几乎优化的材料和过程制造临床假体，并将评估新衬里材料的临床服务性，并将其与对照Molloplast-B进行比较。拟议的商业应用：研究的潜在商业应用是改进的软义齿衬里材料的开发，这些材料具有永久弹性，与义齿碱基聚合物的良好粘结，低水吸附和溶解度，并且适用于临床应用。