NONBLOOD CONTACTING BIVENTRICULAR SUPPORT

非血液接触双心室支撑

• 批准号: 6056243
• 负责人: JAMES E LOWE
• 金额: $ 56.82万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-24 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6056243
• 关键词: aortic balloon pump; atrial fibrillation; bioengineering /biomedical engineering; biomaterial development /preparation; biomaterial evaluation; biomedical equipment development; biomedical equipment safety; cardiogenic shock; circulatory assist; coronary bypass; diaphragm; heart failure; heart ventricle; human subject; medical rehabilitation related tag; sheep

Direct Mechanical Ventricular Actuation (DMVA) is a non-blood contacting method for circulatory support which can be used in the failing heart, asystolic heart or fibrillating heart. The technology utilizes a contoured cup which attaches itself to both ventricles via a continuous vacuum. Once attached, positive and negative pneumatic forces move the diaphragm within the assist cup to "actuate" the ventricles into respective systolic and diastolic configurations. DMVA was originally designed only for short-term circulatory support in patients who suffered cardiac arrest refractory to standard resuscitative measures. Recent advances in support cup design and drive-line mechanics strongly suggest that the technology can be further developed to provide safe, effective and economical long-term circulatory support. DMVA has been extensively investigated in the Principal Investigator's laboratory over the past 4 years. Based on experimental results, Institutional Review Board approval was recently obtained for human use. DMVA support has been applied to 3 patients with refractory cardiogenic shock with 2 long-term survivors. The specific aims of the planned research are designed to perfect DMVA technology for both short-term and long-term, circulatory support. The planned studies to be carried out over the 4-year period of support include: 1) development of a DMVA Mock Circulation for in vitro cup testing for reliability and effectiveness of pumping under various pathologic states, 2) development of durable DMVA cups using modern industrial fabrication techniques with our Duke Biomedical Engineering and industrial consultants, 3) determine the effects of asynchronous versus synchronous DMVA support in an animal model, 4) determine the effects of DMVA on experimentally placed coronary artery bypass grafts, 5) apply the improved DMVA cups for total chronic circulatory support in animals, and 6) continue to apply DMVA support in select patients with refractory cardiogenic shock. Data from the planned studies will determine in detail the advantages and limitations of this form of biventricular assistance for total circulatory support. The eventual goal is to produce safe, reliable and effective DMVA support systems for widespread clinical use.

直接机械心室致动（DMVA）是一种非血接触 可以在失败的心脏中使用的循环支持方法， 心理心脏或纤颤的心。 该技术利用 轮廓杯，通过连续的 真空。 一旦附着，正和负气动就会移动 辅助杯中的隔膜将心室“动摇”到 各自的收缩期和舒张期配置。 DMVA最初是 专为患者的短期循环支持而设计 对标准复苏措施的心脏骤停难治。 最近的 支持杯设计和驱动线机制的进步强烈建议 可以进一步开发该技术以提供安全，有效的 和经济的长期循环支持。 DMVA已广泛 过去的4个 年。 根据实验结果，机构审查委员会 最近获得了批准。 DMVA支持一直 适用于3例具有2个长期难治性心源性休克的患者 幸存者。 计划研究的具体目的旨在 完美的DMVA技术，用于短期和长期循环系统 支持。 计划的研究将在4年内进行 支持包括：1）开发用于体外的DMVA模拟循环 杯子测试可靠性和泵送的有效性 病理状态，2）使用现代的耐用DMVA杯子开发 使用我们的杜克生物医学工程的工业制造技术 和工业顾问，3）确定异步的影响 动物模型中的与同步DMVA支持，4）确定 DMVA对实验放置冠状动脉旁路移植物的影响， 5）将改进的DMVA杯应用于 动物，6）继续在特定患者的患者中应用DMVA支持 难治性心源性休克。 来自计划研究的数据将 详细确定这种形式的优势和局限性 双室辅助，以全循环支持。 最终 目标是生成安全，可靠和有效的DMVA支持系统 广泛的临床用途。

项目成果

Experimental aortocoronary saphenous vein graft function after mechanical cardiac massage with the Anstadt Cup.

用 Anstadt 杯进行机械心脏按摩后实验性主动脉冠状动脉隐静脉移植功能。

• 发表时间: 1996
• 期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
• 作者: Anstadt,MP;Perez-Tamayo,RA;Davies,MG;Hagen,PO;St-Louis,JS;Hendrickson,SC;Abdel-Aleem,S;Reimer,KA;Anstadt,GL;Lowe,JE
• 通讯作者: Lowe,JE

Prolonged total circulatory support using direct mechanical ventricular actuation.

使用直接机械心室驱动延长全循环支持。

• DOI: 10.1097/00002480-199507000-00063
• 发表时间: 1995
• 期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
• 作者: Perez-Tamayo,RA;Anstadt,MP;CothranJr,RL;Reisinger,RJ;Schenkman,DI;Hulette,C;Reimer,KA;Anstadt,GL;Lowe,JE
• 通讯作者: Lowe,JE