BEHAVIORAL EFFECTS OF CANCER TREATMENT

癌症治疗对行为的影响

• 批准号: 2889792
• 负责人: William H Redd
• 金额: $ 10.45万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2889792
• 关键词: behavioral /social science research tag; blood /lymphatic neoplasm; bone marrow transplantation; clinical research; human subject; human therapy evaluation; longitudinal human study; mental health epidemiology; neoplasm /cancer immunotherapy; neoplasm /cancer surgery; posttraumatic stress disorder; psychological stressor; psychophysiology; quality of life

This ADAMHA RSDA competing continuation application is requested to allow William H. Redd, Ph.D. to transfer his current fiver RSDA (with three years of funding remaining) from Sloan-Kettering Cancer Center to the Mt. Sinai Medical Center, where he will be appointed as a professor, July I, 1997. This application is an update of the proposal reviewed and funded in June 1994. NIMH regulations require re-review in order for a grantee to transfer a RSDA. significant number of bone marrow transplantation (BMT) survivors continue to experience psychosocial problems and occupational difficulties after completion of their cancer treatment Many of these symptoms are consistent with the characteristic symptoms of Post Traumatic Stress Disorder (PTSD), as defined by the American Psychiatric Association's most recent diagnostic manual DSM-IV, 1994). The proposed prospective longitudinal analysis seeks to examine PTSD/ PTSD symptomalogy, psychological distress, and quality of life in BMT survivors. The proposed research will also investigate the contribution of classical role of conditioning and information processing in post-treatment adjustment. BMT patients will participate in detailed psychosocial assessments: at baseline (time of medical preparation), daily during pre BMT, weekly during engraftment and recovery, and at 2-weeks post discharge and 6 & 12- months post-BMT. Specific aims are 1) to explore the longitudinal expression of PTSD symptomatology and psychological distress following BMT treatment; 2) to determine the role of demographic, illness, treatment and psychological variables in the development and severity of PTSD/PTSD symptomatology, psychological distress and off-treatment quality of life; 3) to assess how patients' physical and psychological reactions during the course of BMT treatment and their cognitive appraisals of the BMT treatment experience relate to the development of PTSD/PTSD symptomatology, psychological distress, and reduced quality of life; 4) to investigate ho psychosocial variables mediate and/or moderate the relation between patient baseline characteristics and symptomatology. proposed research will contribute to our understanding of PTSD and PTSD-like symptoms in survivors of treatment for life threatening illness. It should also help determine the validity and utility of the PTSD diagnosis in understanding adjustment difficulties in cancer survivors. It will advance efforts toward prevention of psychological morbidity by identifying those at risk for post-treatment distress so that appropriate interventions can be instituted.

此Adamha RSDA竞争连续申请被要求 允许William H. Redd博士转移他目前的Fiver RSDA （剩下三年的资金）来自斯隆 - 凯特癌 西奈山医疗中心的中心，将被任命 作为教授，1997年7月1日。此申请是 提案审查并于1994年6月进行了资助。NIMH法规要求 重新审查是为了使受赠人转移RSDA。重要的 骨髓移植（BMT）幸存者的数量继续 经历社会心理问题和职业困难 完成癌症治疗后，许多症状 与创伤后的特征症状一致 应力障碍（PTSD），如美国精神病学所定义 协会的最新诊断手册DSM-IV，1994）。这 拟议的前瞻性纵向分析旨在检查PTSD/ PTSD症状，心理困扰和生活质量 BMT幸存者。拟议的研究还将调查 调理和信息的经典作用的贡献 处理后调整中的处理。 BMT患者会 参加详细的社会心理评估：基线（时间 医疗准备），每天在BMT之前，每周一次 植入和恢复，在出院后2周，6＆12-- BMT之后的月份。具体目的是1）探索纵向 PTSD症状和心理困扰的表达 BMT治疗后； 2）确定人群的作用， 发育中的疾病，治疗和心理变量 PTSD/PTSD症状，心理困扰的严重程度 和非治疗生活质量； 3）评估患者的方式 BMT过程中的身体和心理反应 治疗及其对BMT治疗的认知评估 经验与PTSD/PTSD症状的发展有关， 心理困扰和生活质量降低； 4）到 调查HO心理社会变量中介和/或适应 患者基线特征与 症状学。拟议的研究将有助于我们 了解幸存者的PTSD和PTSD样症状 治疗生命威胁疾病。它也应该有帮助 确定PTSD诊断的有效性和效用 了解癌症幸存者的调整困难。会 提前努力预防心理发病率 确定有治疗后遇险风险的人 可以制定适当的干预措施。