CIS-RETENOIC ACID, CISPLATIN AND RADIATION FOR HEAD/NECK CANCER

顺式维甲酸、顺铂和放射治疗头颈癌

• 批准号: 5221313
• 负责人: ROBERT A WEISMAN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5221313
• 关键词: 13 cis retinoate; cis platinum compound; clinical research; clinical trial phase I; combination cancer therapy; dosage; drug screening /evaluation; head /neck neoplasm; human subject; human therapy evaluation; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; nutrition related tag; pharmacokinetics; squamous cell carcinoma; vitamin therapy

Phase I clinical trial of escalating dose of 13-cis-retinoic acid given orally to patients with stage iv squamous cell carcinoma of head and neck who are receiving weekly cycles of cisplatin and concurrently undergoing standard course of therapeutic radiation. To monitor and quantify toxicity of regimen and measure tumor response.

13-顺式视黄酸剂量递增的 I 期临床试验 头颈部鳞状细胞癌 IV 期患者口服 每周接受顺铂周期并同时接受 放射治疗的标准疗程。 监测和量化 方案的毒性并测量肿瘤反应。