CYTOMEGALOVIRUS RETINITIS RETREATMENT TRIAL

巨细胞病毒视网膜炎治疗试验

• 批准号: 5218005
• 负责人: MURK-HEIN HEINEMANN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5218005
• 关键词: AIDS; AIDS therapy; antiviral agents; clinical research; clinical trials; combination chemotherapy; cytomegalovirus; foscarnet; ganciclovir; human subject; human therapy evaluation; opportunistic infections; relapse /recurrence; retinitis

A multicenter clinical trial whose primary objective is to compare the safety and efficacy of 3 therapeutic regimens for AIDS-related CMV retinitis in patients treated with foscarnet or ganciclovir and whose retinitis progressed or recurred. Also, the safety and efficacy of continuing to treat patients with same anti-CMV drug versus being switched to the alternative drug as a result of randomization will be compared to those assigned by randomization to continue treatment with the same drug.

一项多中心临床试验，其主要目的是比较 艾滋病相关巨细胞病毒的 3 种治疗方案的安全性和有效性 接受膦甲酸或更昔洛韦治疗且其患者患有视网膜炎的患者 视网膜炎进展或复发。此外，其安全性和有效性 继续使用相同的抗 CMV 药物治疗患者与 由于随机化的结果将改用替代药物 与随机分配继续治疗的患者相比 同一种药物。