SCOR IN HEART FAILURE

心力衰竭的评分

• 批准号: 2232653
• 负责人: HAROLD CARL STRAUSS
• 金额: $ 118.67万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-02-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2232653
• 关键词: congestive heart failure; pathology

Heart Failure Specialized Center of Research (SCOR) is a multidisciplinary, interdepartmental clinical and basic research program that is directed at the reduction of death and disability from congestive heart failure. This proposed research program uses state of the art molecular biological techniques to address clinical, pharmacological and physiological questions relevant to the management of heart failure patients. The clinical component of this application encompasses research into the pathophysiology of exercise intolerance in ambulatory patients with congestive heart failure. The fundamental component encompasses research into the most fundamental biological processes by the mechanism by which calmodulation overexpression causes cardiac myocyte hypertrophy and hyperplasia; the mechanisms underlying the activation and desensitization of alpha- adrenergic receptors; the mechanisms underlying adenosine receptor mediated transmembrane signalling in vascular smooth muscle cells; and the mechanism of gating and drug binding to a transient outward potassium channel that plays an important role in cardiac repolarization. This integrated effort is aimed at translating the results of the applicant's diverse research efforts concerning the pathophysiology, clinical, pharmacologic and surgical therapy into the clinic to reduce death and disability from congestive heart failure.

心力衰竭专业研究中心 (SCOR) 是一个多学科、 跨部门的临床和基础研究项目 减少充血性心力衰竭导致的死亡和残疾。 这 拟议的研究计划使用最先进的分子生物学 解决临床、药理学和生理问题的技术 与心力衰竭患者的治疗相关。 临床上 该应用程序的组成部分包括病理生理学研究 流动性充血性心脏病患者运动不耐受的影响 失败。 基本组成部分包括对最重要的领域的研究 钙调调节机制的基本生物过程 过度表达导致心肌细胞肥大、增生；这 α-激活和脱敏的机制 肾上腺素能受体；腺苷受体介导的机制 血管平滑肌细胞中的跨膜信号传导；和机制 门控和药物与瞬时外向钾通道的结合 在心脏复极中起重要作用。 这种综合努力 旨在转化申请人多样化研究的成果 在病理生理学、临床、药理学和 手术治疗进入临床以减少死亡和残疾 充血性心力衰竭。