THIOL CONTAINING LIGANDS FOR PB(II) AND BI(III)

PB(II) 和 BI(III) 的含硫醇配体

• 批准号: 5201267
• 负责人: P M BEITZEL
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201267
• 关键词: chelating agents; chemical synthesis; lead; ligands; metal complex; sulfur; thiols

The goal of the project is to synthesize bifunctional ligands which have a high affinity for Pb(II) and Bi(III) by virtue of the presence of sulfur donor atoms. simple thiolate ligands such as dimercaptosuccinic acid have been shown to form complexes of high stability with both ions (Kf for the 1:2 BiDMSA complex in log 43.87), yet appropriate multidentate chelating agents suitable for linkage to monoclonal antibodies are not yet available. As such, systematic exploration of the chemistry of incorporating thiol donor groups into both existing and new acyclic and cyclic chelating agents is planned. Appropriated precursor molecules will be synthesized to allow testing of the methodology for the incorporation of thiols into new chelating agents for protein modification.

该项目的目标是合成双功能配体，其具有 由于硫的存在，对 Pb(II) 和 Bi(III) 有高亲和力 供体原子。简单的硫醇配体如二巯基丁二酸具有 已被证明可以与两种离子形成高稳定性的复合物（Kf 为 1:2 BiDMSA 复合物（对数 43.87），但具有适当的多齿螯合 目前还没有适合连接单克隆抗体的试剂 可用的。 因此，对化学的系统探索 将硫醇供体基团纳入现有的和新的无环和 计划使用环状螯合剂。 适当的前体分子将 被综合以允许测试合并方法 将硫醇转化为用于蛋白质修饰的新螯合剂。