CLINICAL PHARMACOLOGY OF THE CENTRAL NERVOUS SYSTEM

中枢神经系统的临床药理学

• 批准号: 4696327
• 负责人: D C JIMERSON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696327
• 关键词: 3 methoxy 4 hydroxyphenylethyleneglycol; antidepressants; blood chemistry; brain metabolism; catecholamines; central nervous system; dopamine; drug metabolism; epinephrine; fluorimetry; gas chromatography; human subject; mass spectrometry; neuropharmacology; neurotransmitter metabolism; norepinephrine; nutrition related tag; psychopharmacology; psychotropic drugs; radioimmunoassay; urinalysis

The purpose of this study is to develop techniques for studying central nervous system monoamine metabolism in man, and to assess the value of peripheral neurotransmitter measures as indices of central function. Clinical studies evaluating alterations of norepinephrine metabolites in plasma were continued. Differential relationships between norepinephrine activity and cortisol levels were demonstrated in healthy volunteers and bulimic patients, in comparison to previous results in depressed patients. A study of a proposed new antidepressant drug rolipram on brain norepinephrine function was performed in laboratory rodents.

这项研究的目的是开发研究中央的技术 人类的神经系统单胺代谢，并评估 周围神经递质量度作为中心功能指标。 评估去甲肾上腺素代谢物改变的临床研究 血浆继续。 去甲肾上腺素之间的差异关系 在健康的志愿者中证明了活性和皮质醇水平 与以前的抑郁症患者相比，鸡不利的患者。 一项针对大脑上提出的新抗抑郁药rolipram的研究 去甲肾上腺素功能在实验室啮齿动物中进行。