Developmental Clinical Studies - development of vitamin D therapy to prevent acute lung injury.

发育临床研究 - 开发维生素 D 疗法以预防急性肺损伤。

• 批准号: G1100196/1
• 负责人: David Thickett
• 金额: $ 62.53万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100196%2F1
• 关键词: Developmental; Clinical; Studies; development; vitamin

The aim of this research is to develop vitamin D as a therapy to prevent acute lung injury. Acute lung injury ALI is a major cause of lung failure in critically ill patients. Most patients affected are of working age and survivors experience a significant reduction in health-related quality of life, with 46% unable to return to work within 12 months. Currently, apart from invasive protective ventilation, no therapy has been conclusively proven to reduce mortality or improve functional outcome in survivors. This represents a major unmet health need. By undertaking this research we will establish if simple and cheap replacement of vitamin D influences the development and severity of acute lung injury.

这项研究的目的是开发维生素D作为预防急性肺损伤的疗法。急性肺损伤ALI是重症患者肺部衰竭的主要原因。受影响的大多数患者都是工作年龄，幸存者的生活质量大大降低，其中46％的人无法在12个月内重返工作岗位。目前，除了侵入性的防护性通风外，尚无最终证明可以降低死亡率或改善幸存者的功能结果的治疗。这代表了主要的未满足健康需求。通过进行这项研究，我们将确定维生素D的简单廉价替代是否会影响急性肺损伤的发展和严重程度。