EFFECTS OF ETHANOL ON METABOLIC CONTROL PROCESSES

乙醇对代谢控制过程的影响

• 批准号: 3817379
• 负责人: R L VEECH
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3817379
• 关键词: NAD(H) phosphate; acetaldehyde; acetates; alcohol dehydrogenase; alcoholic beverage consumption; alcoholism /alcohol abuse; aldehyde dehydrogenases; calcium metabolism; enzyme mechanism; ethanol; fatty acid metabolism; glucose metabolism; laboratory rat; liver metabolism; other phosphotransferase; pyrophosphates; starvation

Ethanol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde, and acetaldehyde is then further metabolized by aldehyde dehydrogenase to acetate. Most emphasis in the study of the metabolites of ethanol has focused on acetaldehyde. However, the blood concentration of this compound rarely exceeds 10 uM, while the blood concentration of acetate approaches 2 mM even after the consumption of moderate amounts of ethanol. This study was undertaken to elucidate the consequences of acetate metabolism on the major metabolic pathways. Administration of acetate to starved rats causes a number of changes in hepatic metabolite concentrations, the most striking of which are (1) a greater than one hundredfold elevation :n pyrophosphate concentration, (2) a fivefold elevation in calcium, (3) a marked reduction in the cytosolic (NADP-+)/(NADPH) redox ratio, and (4) a twofold increase in glucose concentration.

乙醇在肝脏中被乙醇脱氢酶代谢为 乙醛，然后乙醛进一步代谢 乙醛脱氢酶转化为乙酸。 学习中最重视的是 乙醇的代谢物主要集中在乙醛上。 然而， 该化合物的血液浓度很少超过 10 uM， 而醋酸盐的血液浓度即使在 消耗适量的乙醇。 这项研究是 旨在阐明醋酸盐代谢对 主要代谢途径。 对饥饿的大鼠施用醋酸盐会导致许多 肝脏代谢物浓度的变化是最显着的 (1) 高于一百倍的高度：n 焦磷酸盐浓度，(2) 钙含量增加五倍， (3) 胞质 (NADP-+)/(NADPH) 氧化还原显着减少 比率，以及（4）葡萄糖浓度增加两倍。