Nucleic Acid Aptamers As Research Tools And Diagnostic Reagents In Amyloid Disease

核酸适体作为淀粉样蛋白疾病的研究工具和诊断试剂

• 批准号: G0900958/1
• 负责人: Peter Stockley
• 金额: $ 123.02万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0900958%2F1
• 关键词: Nucleic; Acid; Aptamers; Research; Tools

A number of major diseases such as Alzheimer s are now known to be caused by an error in the behaviour of the proteins within our bodies. Normally soluble proteins become sticky and begin to clump together forming aggregates called amyloid. This clumping process causes damage to the tissues within the body, for example the death of brain cells in Alzheimer s disease resulting in memory loss and ultimately dementia. We are proposing to produce molecules that in the long term could be used by doctors to screen for the presence of amyloid, allowing early detection and possibly even treatment of these devastating diseases.

现在已知许多主要疾病（例如阿尔茨海默氏症）是由于我们体内蛋白质的行为错误引起的。通常情况下，可溶性蛋白会变得粘稠，并开始将形成称为淀粉样蛋白的聚集体结合在一起。这种结块过程会损害体内的组织，例如，阿尔茨海默氏病中脑细胞死亡，导致记忆力丧失并最终导致痴呆症。我们提议生产分子，从长远来看，医生可以使用淀粉样蛋白的存在来筛查，从而允许早期发现甚至可以治疗这些毁灭性疾病。