GENETIC AND CYTOGENETIC STUDIES OF MENTAL RETARDATION

智力低下的遗传和细胞遗传学研究

• 批准号: 3096855
• 负责人: SAMUEL A. LATT
• 金额: $ 49.41万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-01-01 至 1987-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3096855
• 关键词: cytogenetics; gene expression

Cytogenetic, cell genetic and recombinant DNA techniques will be employed in obtaining an understanding of fundamental biological principles potentially relevant to mental retardation. Gene mapping, principally of mouse and man, will be carried out to determine general principles regarding gene organization as well as to elucidate in detail the map of specific regions (such as the human X chromosome), especially relevant to mental retardation syndromes. Somatic cell genetic studies will be conducted of selected problems, such as cell fusion and cellular uptake of exogenous DNA, of potential importance to the analysis and management of inherited disorders. DNA studies of the mouse and human X chromosomes will be made in order to study the comparative evolution of various sequences and in order to examine the chemical basis of X-inactivation.

将采用细胞遗传学、细胞遗传学和重组 DNA 技术 潜在地了解基本生物学原理 与智力低下有关。 基因图谱，主要是小鼠和人的基因图谱， 将进行以确定有关基因组织的一般原则 以及详细阐明特定区域的地图（例如人类 X 染色体），尤其与智力低下综合征相关。 体细胞 将对选定的问题进行细胞遗传学研究，例如细胞融合 和细胞对外源 DNA 的摄取，对分析具有潜在重要性 和遗传性疾病的管理。 小鼠和人类 X 的 DNA 研究 将制造染色体以研究各种物种的比较进化 序列并检查 X 失活的化学基础。