CONFORMATION AND ELECTRONIC STRUCTURE OF BIOLOGICAL MOLECULES

生物分子的构象和电子结构

• 批准号: 3964451
• 负责人: W A EATON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3964451
• 关键词: Raman spectrometry; atomic absorption spectrometry; birefringences; carbon monoxide; chemical structure function; conformation; dichroism; heme; hemoglobin As; hemoprotein structure; laser spectrometry; ligands; molecular energy level; photolysis; quantum chemistry

A transient laser spectrometer has been developed for measurements of optical absorption spectra and kinetics of hemoglobin conformational changes and ligand rebinding following photolysis of the carbon monoxide complex. Molecular dynamics calculations are being carried out to simulate the heme and globin structural changes and the ligand motion following photolysis.

已经开发了瞬态激光光谱仪以测量 血红蛋白构象的光学吸收光谱和动力学 一氧化碳光解后，变化和配体重新插入 复杂的。 正在进行分子动力学计算以模拟 血红素和球蛋白结构的变化以及配体运动以下 光解。