ANTISERA AND RECOMBINANT PROTEINS FOR RESEARCH IN AIDS

用于艾滋病研究的抗血清和重组蛋白

• 批准号: 3597231
• 负责人: GEOFF YARRANTON
• 金额: $ 56.95万
• 依托单位: CELLTECH, LTD.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-06-10 至 1993-06-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3597231
• 关键词: AIDS; antiviral agents; antiviral antibody; biological products; biotechnology; disease /disorder model; genetic manipulation; human immunodeficiency virus 1; immunological substance; viral vaccines; virus protein

OBJECTIVE: The development of antiviral drugs and vaccines effective against HIV has been hampered by the absence of standardized reagents. Such reagents are necessary for the following: to identify viral epitopes required for immunity, to characterize the nature of the immune response to infection and immunization, to facilitate the development of improved methods to monitor viral load in patients undergoing treatment, to characterize the extent and significance of antigenic drift as it occurs in HIV and related retroviruses, and to establish animal models of AIDS. It is the purpose of this solicitation to support research activities needed to provide these reagents and to supply reagents to the AIDSP for distribution to the scientific community. It is the purpose of this solicitation to clone genes, express functional proteins from the genes and make antisera to those proteins. The products produced under this contract will be used to support the research activities of the scientific community. Some reagents of these reagents exist within government, academic and industry laboratories, but NIAID needs a centralized production resource to meet the needs of the scientific community. The NIAID needs access to significant quantities of the noted materials to support the efforts of the National Cooperative Drug Discovery Groups, the National Vaccine Development Groups, the AIDS Clinical Study Groups, the Programs of Excellence in Basic Research on AIDS, and other more specific programs initiated by NIAID.

目的：抗病毒药物和疫苗的开发 由于缺乏有效的艾滋病毒防治措施， 标准化试剂。 此类试剂对于 以下：识别免疫所需的病毒表位， 描述对感染的免疫反应的性质和 免疫，以促进改进方法的开发 监测接受治疗的患者的病毒载量， 描述抗原漂移的程度和意义 发生在艾滋病毒和相关逆转录病毒中，并建立动物 艾滋病模型。 此次征集的目的是为了支持 提供这些试剂和供应所需的研究活动 试剂到 AIDSP 分发给科学 社区。 本次征集的目的是克隆基因、表达 来自基因的功能蛋白并针对这些蛋白制造抗血清 蛋白质。 根据本合同生产的产品将用于 支持科学界的研究活动。 这些试剂中的一些试剂存在于政府内部， 学术和工业实验室，但 NIAID 需要一个集中的 生产资源满足科学发展的需要 社区。 NIAID 需要获得大量的 支持国家努力的上述材料 药物发现合作小组、国家疫苗 发展小组、艾滋病临床研究小组、 艾滋病基础研究卓越计划及其他 NIAID 发起了更具体的计划。