TREATMENT OF AIDS-RELATED KAPOSI'S SARCOMA

艾滋病相关卡波西肉瘤的治疗

• 批准号: 3853265
• 负责人: R YARCHOAN
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853265
• 关键词: AIDS; Kaposi's sarcoma; angiogenesis; antineoplastics; clinical trials; drug adverse effect; growth inhibitors; human subject; human therapy evaluation; neoplasm /cancer chemotherapy; neoplastic cell; pentosan; tissue /cell culture

Kaposi's sarcoma (KS) was one of the first AIDS-defining illness identified, and continues to be a source of considerable morbidity and mortality. The most current information regarding the pathogenesis and biology indicate that a variety of cellular cytokines and products, including basic fibroblast growth factor (FGF) are involved in the growth of KS, particularly in stimulating angiogenesis and neovascularization. Pentosan polysulfate is a sulfated polysaccharide (MW 6000 Daltons) that has been used in Europe as an anticoagulant for many years. Recently, pentosan has been shown to block cell surface receptor binding of FGF and to possess activity against certain FGF-dependent tumor cell lines. We thus instituted a feasibility (pilot) study administering pentosan to patients with AIDS-KS. Sixteen patients were enrolled in the trial. While no patient had either a complete or partial response, 7 patients had stable disease which might indicate a stabilization resulting from an inhibition of growth factors. The dose-limiting toxicities identified were thrombocytopenia and anticoagulation. There were no significant alterations in CD4 cells in [HIV p24 antigen levels. We have developed a KS cell line and are now attempting to develop other therapeutic strategies.

卡波西的肉瘤（KS）是定义的第一个艾滋病之一 确定并继续是相当大的发病率的来源 死亡。 有关发病机理和 生物学表明各种细胞细胞因子和产物， 包括基本成纤维细胞生长因子（FGF）参与 KS的生长，特别是在刺激血管生成和 新血管形成。 戊糖多硫酸盐是硫酸化的多糖 （MW 6000 daltons）在欧洲用作抗凝剂 多年。 最近，已显示五角星阻塞细胞表面 FGF的受体结合并具有某些活性 FGF依赖性肿瘤细胞系。 因此，我们建立了可行性 （试点）研究为AIDS-KS患者进行五角星。 十六 患者参加了试验。 虽然没有病人有 完全或部分反应，7例患者患有稳定的疾病，可能 表明由于抑制生长因子而产生的稳定。 确定的剂量限制性毒性是血小板减少症和 抗凝。 CD4细胞中没有明显改变 [HIV P24抗原水平。 我们已经开发了KS细胞系，现在 试图制定其他治疗策略。