OBSTRUCTIVE SLEEP APNEA SYNDROME--NEUROENDOCRINOLOGY AND VENTILATION RESPONSE

阻塞性睡眠呼吸暂停综合征——神经内分泌学和通气反应

• 批准号: 3849467
• 负责人: DAVID RAPOPORT
• 金额: --
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3849467
• 关键词: adrenocorticotropic hormone; apnea; catecholamines; clinical trials; endorphins; hormone regulation /control mechanism; human subject; human therapy evaluation; naloxone; neuroendocrine system; prolactin; respiratory airway pressure; somatotropin

The study will test (1) if OSAS causes secretion of ACTH, cortisol, growth hormone and beta-endorphin, (2) if treatment of OSAS with nasal continuous positive airway pressure abolishes the neuroendocrine response, and (3) if the post-apneic ventilatory response and the response to flow resistive loading can be acutely restored to normal by naloxone.

该研究将测试（1）如果OSA引起ACTH，皮质醇，生长的分泌 激素和β-内啡肽，（2）如果用鼻连续处理OSA 阳性气道压力废除神经内分泌反应，（3） 公共通气后反应和对流动电阻的响应 纳洛酮可以急性恢复到正常。