LAMININ RECEPTOR AND ITS ROLE IN THE FUNCTION OF NATURAL KILLER CELLS

层粘连蛋白受体及其在自然杀伤细胞功能中的作用

• 批准号: 3916391
• 负责人: G J BRYANT
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3916391
• 关键词: binding proteins; hormone receptor; humoral immunity; laboratory mouse; laminin; metastasis; neoplasm /cancer immunology; protein metabolism; receptor; receptor binding

Natural killer (NK) cells, a subpopulation of large granular lymphocytes (LGL) are involved in the spontaneous lysing of tumor or virally infected target cells. The killing action requires binding of the killer cells to the target cells. The role of the laminin receptor in this process of specific binding is being examined in our laboratories. Using murine NK cells, the presence of laminin-like molecule and a receptor for laminin binding has been established (Kd 10-11 M, approximately 990,000 receptors/cell). Further studies will attempt to define and compare the receptor on NK cells versus the already established laminin receptor located on many tumor cells; the interactions between these two receptors during cell lysis will be explored.

自然杀伤 (NK) 细胞，大颗粒细胞亚群 淋巴细胞（LGL）参与肿瘤的自发裂解 或病毒感染的靶细胞。 杀戮行动需要 杀伤细胞与靶细胞的结合。 的作用 层粘连蛋白受体在这个特异性结合过程中 在我们的实验室进行了检查。 使用小鼠 NK 细胞，存在 层粘连蛋白样分子和层粘连蛋白结合受体的 已建立（Kd 10-11 M，约 990,000 受体/细胞）。 进一步的研究将尝试定义和比较受体 NK 细胞与已建立的层粘连蛋白受体的比较 对许多肿瘤细胞；这两个受体之间的相互作用 将探讨细胞裂解过程中的情况。