PHILADELPHIA PEDIATRIC AIDS CLINICAL TRIAL UNIT

费城儿科艾滋病临床试验中心

• 批准号: 3548021
• 负责人: Stuart E Starr
• 金额: $ 99.34万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-03-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3548021
• 关键词: AIDS; child (0-11); clinical trials; communicable disease transmission; congenital infection; cooperative study; hemophilia As; human immunodeficiency virus 1; human pregnant subject; human subject; intravenous drug abuse; nervous system infection; opportunistic infections; pediatric AIDS; virus related neoplasm /cancer

The Children's Hospital of Philadelphia (CHOP) and St. Christopher's Hospital for Children (SCHC), currently linked through the Circle of Care, a HRSA Pediatric AIDS Demonstration Project, propose to form a Philadelphia Pediatric AIDS Clinical Trials Unit. The two institutions will enroll at least 50 human immunodeficiency virus-infected children per year in phase I, phase II, and phase III trials. Subjects will be recruited from existing patient populations and through community outreach efforts by culturally sensitive individuals. Obstetrical and perinatal research will be conducted at hospitals allied and/or associated with the two pediatric hospitals: Temple University Hospital with SCHC, Thomas Jefferson University Hospital and the Hospital of the University of Pennsylvania with CHOP. Pregnant women and children of minority groups, predominantly African-Americans and Latinos, will comprise close to 90% of the patient population. Recruitment of drug abusers and their children will be facilitated by our consortium arrangement. Hemophiliac children will also be included in clinical studies. The proposed Philadelphia Pediatric ACTU will facilitate basic, as well as clinical research; and provide ancillary services for HIV-infected children and their families, in addition to fulfilling its primary mission as a clinical trials unit.

费城儿童医院（Chop）和圣克里斯托弗（St. Christopher） 儿童医院（SCHC），目前通过护理圈联系 HRSA儿科艾滋病示范项目，建议组建费城 小儿艾滋病临床试验单元。 这两个机构将注册 每年至少有50个人类免疫缺陷病毒感染的儿童 I，II期和III期试验。 主题将从 现有的患者人群以及通过社区推广工作 文化敏感的个体。 产科和围产期研究将 在医院同盟和/或与两个小儿相关的医院进行 医院：SCHC的坦普尔大学医院，托马斯·杰斐逊 大学医院和宾夕法尼亚大学医院 劈。 孕妇和少数群体的儿童，主要是 非裔美国人和拉丁美洲人将占患者的90％ 人口。 招募吸毒者及其子女将 由我们的财团安排促进。 血友病儿童也会 被包括在临床研究中。 拟议的费城小儿actu 将促进基本和临床研究；并提供辅助 除了为艾滋病毒感染的儿童及其家人提供服务 履行其作为临床试验部门的主要任务。