ASSESSMENT AND TREATMENT OF VOICE DISORDERS

声音障碍的评估和治疗

• 批准号: 3775455
• 负责人: DIANE M BLESS
• 金额: --
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3775455
• 关键词: audiotape; biomaterial compatibility; biomaterial evaluation; biomechanics; clinical trials; communication disorders; computer simulation; diagnosis design /evaluation; dogs; electromyography; histology; human subject; human therapy evaluation; image processing; laryngoscopy; larynx; larynx disorder; larynx muscle; neuromuscular system; otorhinolaryngologic surgery; pulmonary respiration; respiratory airflow measurement; respiratory airway pressure; video recording system; viscosity; vocal cords; vocalization; voice

The overall objective of this series of experiments is to determine which phonosurgical method or combination of methods (ie vocal fold augmentation and laryngoplasty) is the most effective treatment of glottic incompetence. This will be approached by longitudinal clinical evaluation of human subjects, laboratory analysis of the impact of intracord injection and laryngoplasties in the excised larynx model and in vivo in the canine larynx model, and with long-term histological studies in the canine larynx. Evaluation will include use of standardized measures and development and application of a new technology, inverse filter technique. The studies address one of the NIDCD National Strategic Planning Committee's recommendation for major clinic research opportunities to expand use of phonosurgical methods through standardized measurements of vocal output before and after surgery, and of simulation modeling to predict vocal outcome before surgical manipulation. As such data gathered should be of significant value and interest to otolaryngologist, vocalogists, and speech scientists as well as to the patients who will benefit from improved treatment. The studies will be conducted in parallel, and in collaboration with other scientists within the Center in order to enhance our understanding of disordered voice production and its surgical remediation.

这一系列实验的总体目的是确定 语音外科方法或方法的组合（即声折额增强 喉成形术）是最有效的发光效果的治疗方法。 这将通过对人类的纵向临床评估来接触 受试者，内部注射影响的实验室分析和 切除的喉模型和犬类体内的喉形成形剂 喉模型，并在犬喉的长期组织学研究。 评估将包括使用标准化措施和开发以及 应用新技术，反过滤技术。 研究 讲述NIDCD国家战略计划委员会的一个 为扩大使用的主要诊所研究机会的建议 通过标准化的声音输出测量的语音外科方法 手术前后以及模拟建模以预测声音 手术操作前的结局。 由于收集的数据应该是 耳鼻喉科医生，嗓音学家和言语的重大价值和兴趣 科学家以及将从改善中受益的患者 治疗。 这些研究将并行进行，并合作进行 与中心内的其他科学家一起增强我们 了解语音生产及其外科手术修复的理解。