Engineering Nature-based Solutions to Tackle Antimicrobial Resistance

工程基于自然的解决方案来解决抗菌素耐药性

• 批准号: EP/Y003101/1
• 负责人: Tao Lyu
• 金额: $ 21.05万
• 依托单位: CRANFIELD UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY003101%2F1
• 关键词: Engineering; Nature; based; Solutions; Tackle

A global survey showed that nearly 10 million people could die each year as a result of antimicrobial resistance (AMR) if the situation is left unchanged. The UK is at the forefront of the global fight against AMR and setting the vision to contain and control AMR by 2040. With reference to the World Health Organisation (WHO) AMR action plan, the global AMR surveillance programme is conducted to understand trends, monitor interventions and develop empiric treatment guidelines for AMR. However, in the water sector, this AMR surveillance effort mainly focuses on conventional treatment stages and does not include nature-based solutions (NbS) infrastructures. Defra's 25-Year Environment Plan, the Water Industry's National Environment Programme, and the Environment Agency 2025 Plan have created a unique opportunity to consider constructed wetlands (CWs) as NbS to deliver wastewater treatment with the provision of environmental and societal co-benefits. All water utilities have deployed their strategies to further promote CWs in sewage works. Therefore, understanding if CW, as an emerging preferred green approach for tertiary treatment in wastewater treatment plants, can act as the final safeguard of natural waters to mitigate such risks while maintaining the contribution of co-benefits is crucial.The experience and lessons learned from the global AMR action could significantly facilitate the current missing NbS focus area on AMR surveillance. Partner Prof Walsh has worked with the WHO on the AMR surveillance programme and the European Joint Programme with a specific focus on AMR. Her expertise and experience will strengthen this project team with key knowledge of the occurrence, transmission, and removal mechanisms of AMR. The AMR investigation in NbS is recently getting attention but suffers from a lack of international-scale assessment with a limited dataset. Partner Dr Carvalho is working on the EU NATURE project to evaluate AMR removal in different CWs from mainland Europe, and the findings will be shared with this project.In this project, PI Dr Lyu will conduct the first field survey in the UK to collect evidence from four different applied CWs in England and Wales with the support of two industrial partners (Anglian Water and Welsh Water). Together with available datasets from the literature and the project partners' network, this project will conduct an international comparative study of AMR removal in CWs as NbS for wastewater treatment. Moreover, the team will also assess the undervalued contribution of reactive oxygen species and indicate adaptations of CWs toward promoting rhizosphere-activated free radicals to oxidise AMR. Ultimately, this project aims to establish a unique collaborative partnership between international academics and industrial practitioners, through sharing experiences, discovering knowledge gaps, exploring technology innovation, and supporting evidence-based policymaking, toward developing a resilient wastewater treatment infrastructure based on NbS to mitigate the spread of AMR.

一项全球调查显示，如果情况保持不变，每年有近 1000 万人可能因抗菌素耐药性 (AMR) 而死亡。英国处于全球抗击AMR的最前沿，并设定了到2040年遏制和控制AMR的愿景。参考世界卫生组织（WHO）AMR行动计划，开展全球AMR监测计划，以了解趋势、监测AMR干预措施并制定针对 AMR 的经验性治疗指南。然而，在水领域，这种抗菌药物耐药性监测工作主要集中在传统的处理阶段，不包括基于自然的解决方案（NbS）基础设施。 Defra 的 25 年环境计划、水务行业的国家环境计划和环境局 2025 年计划创造了一个独特的机会，将人工湿地 (CW) 视为 NbS，以提供废水处理，并提供环境和社会协同效益。所有自来水公司都已部署其战略，以进一步在污水处理厂中推广化学武器。因此，了解化学水作为污水处理厂三级处理的新兴首选绿色方法是否可以作为天然水体的最终保障，以减轻此类风险，同时保持协同效益的贡献至关重要。全球抗微生物药物耐药性行动可以极大地促进目前国家统计局在抗微生物药物耐药性监测方面缺失的重点领域。合作伙伴沃尔什教授曾与世界卫生组织合作开展抗菌素耐药性监测计划和欧洲联合计划，特别关注抗菌素耐药性。她的专业知识和经验将通过抗菌素耐药性的发生、传播和清除机制的关键知识来增强该项目团队的实力。 NbS 的 AMR 调查最近受到关注，但由于缺乏国际规模的评估且数据集有限。合作伙伴Carvalho博士正在开展EU NATURE项目，以评估欧洲大陆不同化学武器的抗菌素耐药性清除情况，研究结果将与该项目共享。在该项目中，PI吕博士将在英国进行首次实地调查以收集证据在两个工业合作伙伴（Anglian Water 和 Welsh Water）的支持下，来自英格兰和威尔士的四个不同的应用 CW。结合文献和项目合作伙伴网络中的可用数据集，该项目将针对污水处理中的 NbS 去除化学武器中的 AMR 进行国际比较研究。此外，该团队还将评估活性氧的被低估的贡献，并指出 CW 对促进根际激活的自由基氧化 AMR 的适应。最终，该项目旨在通过分享经验、发现知识差距、探索技术创新和支持循证决策，在国际学术界和工业从业者之间建立独特的合作伙伴关系，以开发基于 NbS 的弹性废水处理基础设施，以缓解抗菌素耐药性的传播。