EASTERN COOPERATIVE ONCOLOGY GROUP

东方肿瘤合作组

• 批准号: 3558870
• 负责人: WILLIAM R. VOGLER
• 金额: $ 9.7万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-04 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3558870
• 关键词: Bacillus Calmette Guerin vaccine; acute leukemia; acute lymphocytic leukemia; acute myelogenous leukemia; androgen inhibitor; anthracyclines; antineoplastics; autologous transplantation; biological response modifiers; bladder neoplasm; bleomycin; bone marrow transplantation; brain neoplasms; breast neoplasms; bronchogenic carcinoma; calcitonin; cancer information system; cancer prevention; cancer risk; chemoprevention; cis platinum compound; clinical trials; colony stimulating factor; colorectal neoplasms; combination chemotherapy; community health services; cooperative study; cyclophosphamide; cystectomy; cytosine arabinoside; deoxycoformycin; dyserythropoietic anemia; ethers; etoposide; fluorouracil; formamide; gene rearrangement; germ cell neoplasms; hairy cell leukemia; head /neck neoplasm; homologous transplantation; hormone therapy; human subject; human therapy evaluation; ifosfamide; interferons; interleukin 3; interleukin 6; kidney neoplasms; leucovorin; levamisole; lymphocytic leukemia; lymphoma; male castration; melanoma; melphalan; mesothelioma; metastasis; methotrexate; mitomycin C; mitoxantrone; multiple myeloma; nasopharyngeal neoplasms; neoplasm /cancer chemotherapy; neoplasm /cancer diagnosis; neoplasm /cancer genetics; neoplasm /cancer immunology; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; neoplasm /cancer therapy; neoplastic cell; osteosarcoma; ovary neoplasms; phospholipids; polymerase chain reaction; prednisone; prostate neoplasms; rectum neoplasms; sarcoma; small cell lung cancer; tamoxifen; therapy compliance; thrombopoiesis; thyroid neoplasm; tissue /cell culture; tumor antigens; urinary bladder epithelium; vincristine

This application requests support to permit Emory University to participate in clinical trials conducted under the auspices of the Eastern Cooperative Oncology Group. This is a multiple disciplined approach involving collaboration between medical and surgical oncologists, radiation therapists, and pathologists. Emory serves as a regional referral center for cancer and over 2500 newly diagnosed patients are seen annually. The objectives of this proposal are to improve therapy of cancer through research and provide a database for scientific questions regarding cancer biology, epidemiology and clinical trials methodology. The specific aims are to increase case accruals to cooperative group protocols and to expand Emory's participation in the science involved in development of group protocols. Faculty members participate in Group scientific committees. Investigations ongoing at Emory with potential for expansion into group studies are the use of ether phospholipids as purging agents for autologous bone marrow transplantation, the use of calcitonin gene rearrangements for detection of minimal residual disease, combination chemotherapy programs for autologous and allogeneic bone marrow transplantation for lymphomas, hematopoietic growth factors on thrombocytopoiesis, the use of viral oncolysates in melanoma, and the use of cytokine therapy in human colorectal cancer.

本申请要求支持允许埃默里大学参加 在东部合作社主持的临床试验中 肿瘤学小组。 这是一种涉及多个纪律的方法 医学和外科肿瘤学家，辐射之间的合作 治疗师和病理学家。 埃默里（Emory）充当区域推荐中心 对于癌症和2500多名新诊断的患者，每年可见。 该提案的目标是通过 研究并提供有关癌症科学问题的数据库 生物学，流行病学和临床试验方法。 具体的目的是将案件应计向合作组增加 协议并扩大埃默里参与的科学参与 集团协议的开发。教师参加小组 科学委员会。 正在进行的Emory的调查潜力 扩展到小组研究中是将乙醚磷脂用作净化 自体骨髓移植的药物，降钙素的使用 基因重排以检测最小残留疾病，组合 自体和同种异体骨髓的化学疗法计划 淋巴瘤的移植，造血生长因子对 血小板细胞菌，在黑色素瘤中使用病毒性肿瘤酸盐，并使用 人类结肠癌的细胞因子疗法。