International Centre of Excellence in the Treatment of Pathological Fractures

国际病理性骨折治疗卓越中心

• 批准号: EP/Z531248/1
• 负责人: Richard Hall
• 金额: $ 160.6万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FZ531248%2F1
• 关键词: International; Centre; Excellence; Treatment; Pathological

The International Centre-to-Centre collaboration focuses on a significant area of research activity at the three Universities: Pathological Fractures. Fracture rates are expected to surge as the population ages and therefore constitute an urgent, unmet clinical need. Recent co-creation and engagement activities, by the principal investigator, with clinicians and patients, has noted the need for optimised, patient-specific minimally invasive approaches, fracture prevention and the use of localised delivery of therapeutic agents to reduce infection, disease burden and improve bone quality/fixation.The aim of the Centre-to-Centre is to respond to this clinical need and develop an International Centre of Excellence in Research of Pathological Fractures building on the substantial synergies that exist at the three institutions. These include:University of Leeds (UoL): Advanced assessment of medical devices, substantial investments in research for spinal fracturesarising from bone metastases (EPSRC Programme Grant: Oncological Engineering) and peri-prosthetic fractures (Zimmer-Biomet).Uppsala University: Additive Manufacturing for the Life Sciences (VINNOVA funded Competence Centre) and Soft Bone (EIT Health funded) a new generation of low modulus materials designed to fix and prevent fractures in the vertebrae as well as augmentation of the disc.ETH Zurich: Advanced imaging and modelling for pathological fractures (FHT Singapore) and fracture modelling in metastatic disease (EU funded METASTRA).We have further support from 4 industrial partners and UoL.We will bring these attributes together into a more holistic, multidisciplinary collaboration that would significantly enhance the scope for generating novel underpinning engineering science together with appropriate impact through our industrial and healthcare partners.The objectives, building on and enhancing the activities outlined above, are:(1) An integrated, multiscale, Fracture Prediction Modelling Framework to identify bones that are at risk of fracture in given pathologies so as.a. to aid prophylactic interventions to reduce this fracture risk and enable pathology-specific approaches,b. utilise modelling to improve the design of patient-specific/custom made implants.Developed from research at ETHZ and UoL.(2) Develop a Framework for Prophylactically Amenable, Pathology-Specific, Minimally-Invasive interventions to support the load-bearing bone and prevent fracture so to a. significantly inhibit instability, bone pain and, in the vertebra, the potential for spinal cord injury, with the aid of the modelling developed in objective 1b. develop tools and interventions for hip peri-prosthetic fracture.Developed from the research at Uppsala in the Additive Manufacturing for Life Competence Centre and SoftBone and the UoL.(3) A new generation of innovative coatings specific to treatment requirements including reduction in infection & disease burden, promotion of bone growth and enhanced fixation.a. to take advantage of the material and cement technologies outlined in objectives 1 and 2 to provide better functional outcomes.Based on the research at Uppsala and UoL.The proposal is underpinned by a set of cross-cutting themes which are:(1) Responsible Innovation is central to this activity and includes the appropriate (a) ethical principles ensuring that theresearch benefits a wider set of stakeholders including patients, (b) patient and clinical co-creation and meaningfulinteractions so as to enhance the overall design process and (c) appropriate mechanisms that enhance impact includingdissemination, continued patient engagement and exploitation.(2) Workforce development, to ensure that both researchers and investigators have the appropriate knowledge forthe successful execution of the research and wider career aspirations.(3) Equality, Diversity and Inclusion, of both the researchers and the patients involved.

国际中心与中心合作的重点是三所大学的重要研究活动领域：病理骨折。随着人口年龄的增长，断裂率预计会激增，因此构成了紧急，未满足的临床需求。首席研究人员与临床医生和患者的最新共同创造和参与活动已经注意到，需要优化，特定于患者的特定于患者的微创方法，预防裂缝以及使用局部治疗剂的局部交付，以减少感染，疾病负担和改善骨骼质量/固定的疾病，以响应骨骼的目标，并在国际上进行进一步的锻炼。三个机构存在的实质性协同作用。其中包括：利兹大学（UOL）：医疗设备的高级评估，从骨转移研究（EPSRC计划赠款：肿瘤学工程）和围场性裂缝（Zimmer-Biomet）（Zimmer-Biomet）进行的脊柱分裂研究的大量投资。旨在修复和防止椎骨骨折的模量材料以及椎间盘的增强。通过我们的工业和医疗伙伴通过我们的工业和医疗保健伙伴进行适当影响的范围。基于和增强上述活动的目标是：（1）一个集成的，多尺度的，多尺度的，骨折预测的建模框架，以识别给定病理学中骨折风险的骨骼。为了帮助预防性干预措施，以降低这种断裂风险并启用特定病理学方法，b。利用建模来改善特定于患者/定制的植入物的设计。（2）开发了一种用于预防性，病理特异性，最小侵入性干预措施的框架，以支持承重骨负荷骨骼，并防止骨折。借助物镜1b中开发的建模，可以显着抑制不稳定，骨痛和椎骨的潜力。开发了用于髋关节围栏骨折的工具和干预措施。从乌普萨拉（Uppsala）的研究中开发了生命能力中心和软骨和UOL的研究。（3）新一代针对治疗需求的新一代创新涂料，包括减少感染和疾病负担，促进骨骼生长和增强的固定性。A。 to take advantage of the material and cement technologies outlined in objectives 1 and 2 to provide better functional outcomes.Based on the research at Uppsala and UoL.The proposal is underpinned by a set of cross-cutting themes which are:(1) Responsible Innovation is central to this activity and includes the appropriate (a) ethical principles ensuring that theresearch benefits a wider set of stakeholders including patients, (b) patient and clinical共同创造和有意义的互动，以增强整体设计过程以及（c）增强影响的适当机制，包括污染，持续的患者参与和剥削。（2）劳动力发展，以确保研究人员和研究人员都具有适当的研究知识，以使研究的成功执行和更广泛的职业。