PERINATAL EMPHASIS RESEARCH CENTER GRANT

围产期重点研究中心拨款

• 批准号: 3106250
• 负责人: REGINALD C TSANG
• 金额: $ 50.13万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106250
• 关键词: perinatal; prenatal growth disorder

The long-term objective of the Center is to optimize fetal and neonatal growth and to decrease fetal and infant morbidity and mortality. These goals will be accomplished by defining and understanding the basic physiology of fetal and neonatal growth and growth retardation. The overall thesis examined is that specific growth factors are principal regulators of growth and development of the fetus and infant. Drs. Tsang, Clark, Handwerger, and Whitsett provide the administrative organizational framework for the PERC. The Molecular Core provides a central site for molecular norphologic studies and training in in situ hybridization and immunocytochemistry, directed by Dr. Jeff Whitsett. Drs. Korfhagen and Whitsett will identify a progenitor during branching morphogenesis and Type II cytodifferentiation in the fetal lung. Drs. Weaver and Drake will test the hypothesis that the temporal and spatial regulation of pulmonary glycogen metabolism, in the developing respiratory epithelium, is correlated with the pre-translational regulation of glycogen synthase (Project B) and phosphorylase kinase (Project A). Dr. Lieberman examines the thesis that injections of neonatal rats with epidermal growth factor alters ontogenic expression of fibroblast growth factors (FGFs). Drs. Hoath and Donnelly test the thesis that perturbations of perinatal growth; i.e. placental insufficiency or exposure to exogenous EGF, will alter molecular events of early homeothermic adaptation in brown adipose tissue and imprint aberrant patterns of metabolic function in adults. Drs. Chernausek and Smith examine the thesis that carrier proteins for insulin- like growth factors are physiologically-regulated modulators of IGF action during the perinatal period. Dr. Iwamoto tests the hypothesis that the placenta and fetal liver regulated plasma concentrations of IGF-I and thus coordinate fetal growth. Dr. Clark tests the thesis that chronic reduced uteroplacental blood flow leads to asymmetric growth retardation and reduced IGF-I by altering delivery and uptake of oxygen, glucose, and amino acids by the placenta and fetus while also testing the thesis that direct fetal supplementation with nutrients and maternal oxygen administration can prevent IUGR. Thus in this Center, molecular biologic, cellular, physiologic, and a clinical study complement each other in an integrated multidisciplinary study.

该中心的长期目标是优化胎儿和新生儿 生长并降低胎儿和婴儿的发病率和死亡率。 这些 目标将通过定义和理解基本来实现 胎儿和新生儿生长和生长迟钝的生理学。 这 总体论文研究是特定的增长因素是主要的 胎儿和婴儿的生长和发育的调节者。 博士。 Tsang， 克拉克（Clark），Handwerger和Whitsett提供行政组织 Perc的框架。 分子芯为 分子广脑研究和原位杂交和培训 免疫细胞化学，由Jeff Whitsett博士执导。 博士。 Korfhagen和 惠特塞特（Whitsett）将在分支形态发生和类型中识别祖细胞 II胎儿肺中的细胞区分化。 博士。 Weaver和Drake将测试 肺的时间和空间调节的假设 在发育中的呼吸性上皮中，糖原代谢是 与糖原合酶的翻译前调节相关 （项目B）和磷酸化酶激酶（项目A）。 利伯曼博士检查 注射新生大鼠表皮生长因子的论点 改变成纤维细胞生长因子（FGF）的个体表达。 博士。 Hoath和Donnelly检验了围产期生长的扰动的论点； 即胎盘不足或外源EGF的暴露会改变 棕色脂肪组织早期主流适应的分子事件 成人代谢功能的异常模式。 博士。 Chernausek和Smith研究了胰岛素载体蛋白的论点 像生长因素一样是生理调节的IGF作用调节剂 在围产期。 Iwamoto博士检验了以下假设 胎盘和胎儿肝调节IGF-I的血浆浓度，因此 协调胎儿生长。 克拉克博士测试了慢性减少的论文 子宫牙科血流导致不对称的生长迟缓和 通过改变氧气，葡萄糖和氨基的吸收来减少IGF-I 胎盘和胎儿的酸，同时还测试了直接的论文 补充营养和产妇氧气可以补充胎儿 防止IUGR。 因此，在这个中心，分子生物学，细胞， 生理学和一项临床研究在综合中相互补充 多学科研究。