EFRI-EPSRC "ENG-EPSRC EFRI ELiS: Developing probiotic interventions to reduce the emergence and persistence of pathogens in built environments"

EFRI-EPSRC“ENG-EPSRC EFRI ELiS：开发益生菌干预措施以减少建筑环境中病原体的出现和持久性”

• 批准号: EP/X026892/1
• 负责人: Richard Beckett
• 金额: $ 85.35万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX026892%2F1
• 关键词: EFRI; EPSRC; ENG; ELiS; Developing

The project 'ENG-EPSRC EFRI ELiS: Developing probiotic interventions to reduce the emergence and persistence of pathogens in built environments' is an international, multidisciplinary research project that addresses contemporary agendas towards designing and buildings healthy built environments. The project brings together expertise in microbiology, the built environment, infectious disease and antimicrobial resistance (AMR).The proposal responds to the urgency for improving the health of our built environments using an approach that departs from the modern understanding that healthy environments should be based on fewer microbes. Urbanisation, indoor lifestyles and ingrained antibiotic mentalities are selecting for AMR and there is a risk that the current pandemic exacerbates our overreliance on antibiotic approaches which are driving other unintended, longer term public health problems. This approach considers a more nuanced understanding of microbes that recognises that not all microbes are pathogenic. In this manner, future healthy buildings should aim to discriminate between good and bad microbes and in doing so, find ways that can reduce exposure to harmful microbes but also permit the presence and agency of benign environmental microbes roles that are beneficial for human health and the resilience of buildings and cites. The proposal will develop novel probiotic materials for buildings that contain living strains of B.subtilis, a soil derived bacteria that exhibits mechanisms which can inhibit the growth of drug resistant organisms. In the laboratory, we will engineer these probiotic materials for application in buildings that can demonstrate long term survival and ability to prevent AMR bacteria colonisation on these materials and on other building surfaces. In the workshop we will develop novel bio-fabrication approaches that will allow for these living materials to be manufactured in to a series of 1:1 living building component prototypes. These prototypes which will include floor and wall surfaces, furniture components and building panels and cladding will undergo a longitudinal microbial study in a real world building environment at OME, HBBE at Newcastle University, addressing longer term questions of how to progress this approach for building application.

“ENG-EPSRC EFRI ELiS：开发益生菌干预措施以减少建筑环境中病原体的出现和持久性”项目是一个国际性多学科研究项目，旨在解决设计和建造健康建筑环境的当代议程。该项目汇集了微生物学、建筑环境、传染病和抗菌素耐药性 (AMR) 方面的专业知识。该提案响应了改善建筑环境健康的紧迫性，所采用的方法背离了健康环境应以健康为基础的现代理解。更少的微生物。城市化、室内生活方式和根深蒂固的抗生素心态正在选择抗生素耐药性，当前的大流行有可能加剧我们对抗生素方法的过度依赖，从而导致其他意想不到的长期公共卫生问题。这种方法考虑了对微生物的更细致的理解，认识到并非所有微生物都是致病性的。通过这种方式，未来的健康建筑应致力于区分好微生物和坏微生物，并在此过程中找到既能减少接触有害微生物的方法，又能允许有益于人类健康和环境的良性环境微生物的存在和作用。建筑物和城市的复原力。该提案将为含有枯草芽孢杆菌活菌株的建筑物开发新型益生菌材料，枯草芽孢杆菌是一种土壤来源的细菌，具有抑制耐药生物生长的机制。在实验室中，我们将设计这些益生菌材料应用于建筑物中，这些材料可以证明其长期存活并能够防止 AMR 细菌在这些材料和其他建筑物表面上定殖。在研讨会上，我们将开发新颖的生物制造方法，将这些生物材料制造成一系列 1:1 的生物建筑组件原型。这些原型包括地板和墙面、家具组件以及建筑面板和覆层，将在纽卡斯尔大学的 OME、HBBE 的真实世界建筑环境中进行纵向微生物研究，解决如何推进这种建筑应用方法的长期问题。

项目成果

Probiotic Cities

益生菌城市

• 发表时间: 2023
• 作者: Beckett Richard

Probiotic Cities: microbiome-integrated design for healthy urban ecosystems

益生菌城市：健康城市生态系统的微生物组集成设计

• DOI: http://dx.10.1016/j.tibtech.2024.01.005
• 发表时间: 2024
• 期刊: Trends in Biotechnology
• 影响因子: 17.3
• 作者: Robinson J