Using genetics to understand the role of hormones in postmenopausal health

利用遗传学了解激素在绝经后健康中的作用

• 批准号: EP/Y031970/1
• 负责人: Katherine Ruth
• 金额: $ 154.45万
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY031970%2F1
• 关键词: Using; genetics; understand; role; hormones

The health of older women poses significant challenges for future healthcare. Due to longer life-expectancy, women are living for longer after menopause and many will have multiple health conditions as they age, but historically women's health research has been underfunded. Rates of disease increase rapidly after menopause, which is marked by substantial hormonal changes and life-changing symptoms for many women. We have limited understanding of the impact of hormonal changes across life on health after menopause. HEALTH-PM will use state-of-the-art genetic epidemiology to test causal relationships of hormones with postmenopausal diseases and conditions, including menopausal symptoms. I will increase the size of existing genetic studies of hormones up to 10-fold through novel analyses of primary care health records linked to genetic data in 230K people, addressing the complexity of such data. For the first time, widespread genome-wide analyses of postmenopausal disease will be performed, by combining health records data from hospitals, primary care and cancer registry with self-reported menopause status. The objectives of HEALTH-PM are to: 1. Characterise the relative importance of amounts of hormones, duration of exposure or changes in levels for postmenopausal health. 2. Identify a beneficial sex hormone profile over life for good postmenopausal health. 3. Determine whether postmenopausal diseases in women are impacted by hormone changes around menopause over and above the consequences of ageing. 4. Quantify the effects on population health of intervening with hormone treatments. I am uniquely positioned to deliver HEALTH-PM given my expertise in complex trait genetics and health data, becoming a leader of this emerging interdisciplinary field as further large-scale linked genetics and health data are released. Given the possibility for modifying hormone levels with existing therapies, HEALTH-PM offers the potential to substantially improve women's health.

老年妇女的健康对未来的医疗保健构成了重大挑战。由于预期寿命更长，因此女性在更年期后的生活更长，并且随着年龄的增长，许多妇女的健康状况将有多种健康状况，但从历史上看，妇女的健康研究被资助不足。绝经后疾病的发生率迅速增加，这是许多女性的荷尔蒙变化和改变生命的症状的特征。我们对荷尔蒙变化对更年期后健康的影响的影响有限。 Health-PM将使用最先进的遗传流行病学来测试激素与绝经后疾病和疾病（包括绝经症状）的因果关系。我将通过对230K人中遗传数据相关的初级保健健康记录进行新的分析，将激素现有的遗传研究的规模提高到10倍，以解决此类数据的复杂性。通过将医院，初级保健和癌症注册中心的健康记录数据与自我报告的更年期状态相结合，将首次对绝经后疾病进行广泛的全基因组分析。 Health-PM的目标是：1。表征激素量的相对重要性，暴露时间或绝经后健康的水平变化。 2。确定一生中有益的性激素概况，以实现良好的绝经后健康。 3.确定女性的绝经后疾病是否受到更年期周围激素变化的影响，而不是衰老的后果。 4。量化对与激素治疗的中间人群健康的影响。鉴于我在复杂的特质遗传学和健康数据方面的专业知识，随着我在更多的大规模关联遗传学和健康数据中发布了这个新兴的跨学科领域的领导者，我将在复杂的遗传学和健康数据方面提供专业知识。鉴于有可能通过现有疗法修饰激素水平，Health-PM提供了实质上改善妇女健康的潜力。