NewPhaseBio - A new generation of phase field-based models to predict the degradation of biomaterials

NewPhaseBio - 新一代基于相场的模型，用于预测生物材料的降解

• 批准号: EP/Y028236/1
• 负责人: Chuanjie Cui
• 金额: $ 23.84万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY028236%2F1
• 关键词: NewPhaseBio; new; generation; phase; field

Biodegradable materials, such as magnesium (Mg), have attracted significant attention in medical applications due to theirmechanical properties, biocompatibility, and in vivo degradability. However, their use as implant materials is being hindered by theirrapid corrosion rates and mechanical failures - degradation occurs before bone healing. This fellowship builds upon the hypothesisthat these challenges can be overcome by tailoring the mechanical integrity and degradation rates through the development of Mgbasedcomposite materials and Mg alloys with adequate choices of composition. To achieve this, I will develop a new class of phasefield-based models that resolve the electro-chemo-mechanical processes underlying biomaterial degradation, extending the successof phase field approaches to a new discipline (bio-corrosion). Computational predictions will be benchmarked against acomplementary experimental campaign, and subsequently used to map viability regimes and gain fundamental insight that will setthe basis for new Mg-based bioengineering solutions. The goal is to develop a "virtual platform" that will enable tailoringbiocorrosion rates to the desired implant geometry/integrity at the end of its functional life, with the long-term ambition of impactingclinical practice. The feasibility of the research is strengthened by my pioneering work in phase field corrosion for structural materials,and the interdisciplinary collaboration arranged, involving two host supervisors at Imperial College London with a world-leadingreputation in biomaterials (J. Jones) and phase field multi-physics modelling (E. Martinez-Pañeda), and a collaborator leading acomplementary H2020 project focused on experimental testing of Mg and Mg-based composite implants (J. Llorca, PolytechnicUniversity of Madrid and IMDEA Materials).

可生物降解材料，例如镁（Mg），由于其机械性能、生物相容性和体内可降解性，在医疗应用中引起了广泛关注，然而，它们作为植入材料的使用却因其快速腐蚀速率和机械失效（降解）而受到阻碍。该研究建立在这样的假设之上：通过开发镁基复合材料和镁合金并选择适当的成分，可以克服这些挑战。开发一类新的基于相场的模型，解决生物材料降解的电化学机械过程，将相场方法的成功扩展到新学科（生物腐蚀），并将以补充实验活动为基准。随后用于绘制活力状况并获得基本见解，这将为新的基于镁的生物工程解决方案奠定基础。目标是开发一个“虚拟平台”，能够根据所需的植入物定制生物腐蚀速率。我在结构材料相场腐蚀方面的开创性工作以及涉及两位主持人安排的跨学科合作加强了该研究的可行性。伦敦帝国理工学院的导师在生物材料 (J. Jones) 和相场多物理建模 (E. Martinez-Pañeda) 方面享有世界领先的声誉，以及领导补充 H2020 项目的合作者专注于镁和镁基复合植入物的实验测试（J. Llorca、马德里理工大学和 IMDEA Materials）。