NewPhaseBio - A new generation of phase field-based models to predict the degradation of biomaterials

NewPhaseBio - 新一代基于相场的模型，用于预测生物材料的降解

• 批准号: EP/Y028236/1
• 负责人: Chuanjie Cui
• 金额: $ 23.84万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY028236%2F1
• 关键词: NewPhaseBio; new; generation; phase; field

Biodegradable materials, such as magnesium (Mg), have attracted significant attention in medical applications due to theirmechanical properties, biocompatibility, and in vivo degradability. However, their use as implant materials is being hindered by theirrapid corrosion rates and mechanical failures - degradation occurs before bone healing. This fellowship builds upon the hypothesisthat these challenges can be overcome by tailoring the mechanical integrity and degradation rates through the development of Mgbasedcomposite materials and Mg alloys with adequate choices of composition. To achieve this, I will develop a new class of phasefield-based models that resolve the electro-chemo-mechanical processes underlying biomaterial degradation, extending the successof phase field approaches to a new discipline (bio-corrosion). Computational predictions will be benchmarked against acomplementary experimental campaign, and subsequently used to map viability regimes and gain fundamental insight that will setthe basis for new Mg-based bioengineering solutions. The goal is to develop a "virtual platform" that will enable tailoringbiocorrosion rates to the desired implant geometry/integrity at the end of its functional life, with the long-term ambition of impactingclinical practice. The feasibility of the research is strengthened by my pioneering work in phase field corrosion for structural materials,and the interdisciplinary collaboration arranged, involving two host supervisors at Imperial College London with a world-leadingreputation in biomaterials (J. Jones) and phase field multi-physics modelling (E. Martinez-Pañeda), and a collaborator leading acomplementary H2020 project focused on experimental testing of Mg and Mg-based composite implants (J. Llorca, PolytechnicUniversity of Madrid and IMDEA Materials).

由于其机械性能，生物相容性和体内降解性，可生物降解的材料（例如镁（MG））在医疗应用中引起了极大的关注。但是，它们作为植入物材料的使用受到其碎屑腐蚀速率和机械故障的阻碍 - 降解发生在骨骼愈合之前。该奖学金基于以下假设：这些挑战可以通过开发MGBASEDCOMPOSITES材料和MG合金来克服机械完整性和降解速率，并具有足够的组成选择来克服这些挑战。为了实现这一目标，我将开发一种新的基于阶段的基于阶段的模型，该模型可以解决生物材料降解的基础电化学过程，从而将连续的相位场方法扩展到新学科（生物腐蚀）。计算预测将针对互补的实验活动进行基准测试，然后用来绘制生存能力制度并获得基本的见解，这将为新的基于MG的基于MG的生物工程解决方案树立基础。目的是开发一个“虚拟平台”，该平台将在其功能寿命结束时以构型植入物的几何形状/完整性，并带有影响精通练习的长期野心。 The feasibility of the research is strengthened by my pioneering work in phase field corrosion for structural materials, and the interdisciplinary collaboration arranged, involving two host supervisors at Imperial College London with a world-leading reputation in biomaterials (J. Jones) and phase field multi-physics modelling (E. Martinez-Pañeda), and a collaborator leading appropriate H2020 project focused on experimental testing of Mg and Mg-based综合秘密（J. Llorca，马德里理工大学和IMDEA材料）。