European Network on the Supramolecular Chemistry of Carbohydrates

欧洲碳水化合物超分子化学网络

• 批准号: EP/Y028058/1
• 负责人: Anthony Davis
• 金额: $ 33.22万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY028058%2F1
• 关键词: European; Network; Supramolecular; Chemistry; Carbohydrates; European; Network; Supramolecular; Chemistry; Carbohydrates

Carbohydrates are nature's most abundant and versatile molecules and are involved in several diseases (e.g. diabetes, infection, and cancer metastasis) and other regular processes (e.g. fertilization, immune surveillance and inflammatory responses). Understanding, monitoring and intervening in these processes could be exploited in medicinal therapies, glycobiology, and biomedical research in general. Such applications are predicated on the availability of carbohydrate binding molecules (CBMs) that can selectively and supramolecularly (noncovalently) bind a plethora of carbohydrate molecules ranging from simple monosaccharides to complex oligosaccharides and glycoconjugates. Technologies that can be developed based on CBMs include: the separation and isolation of carbohydrate containing molecules; making carbohydrate sensing and detection devices; enabling selective chemistry on (unprotected) carbohydrates; and a range of bio-functional applications. While the expertise to design, synthesize, study and exploit CBMs is mostly European, the research groups active in this emerging field work independent from each other. With this doctoral network grant, we aim to unite this expertise in the 'European Network for the Supramolecular Chemistry of Carbohydrates' (ENSCC). With most of the world's leading minds on the topic and three companies that are spearheading technologies in the field, our ENSCC will be a European powerhouse that will lead the academic field globally for years to come. This will be achieved by sharing expertise, key-infrastructure, molecular building blocks, and -most importantly- by together training the ten PhDs that this doctoral network grant will fund. This training by a unique network of world-leaders, experts in the field and companies with an interest in CBMs will perfectly position our PhD students to further develop the field by continuing their career in academia and/or industry.

碳水化合物是大自然最丰富和通用的分子，并且参与了多种疾病（例如糖尿病，感染和癌症转移）和其他常规过程（例如受精，免疫监测和炎症反应）。一般而言，可以利用了解，监测和干预这些过程中的这些过程中的理解和干预。这种应用是基于碳水化合物结合分子（CBM）的可用性，这些分子（CBM）可以选择性地和超分子（非折叠）结合了从简单单糖到复杂的寡糖和糖二二糖的众多碳水化合物分子。可以基于CBM开发的技术包括：含有分子的碳水化合物的分离和分离；制作碳水化合物感测和检测设备；在（未受保护的）碳水化合物上实现选择性化学；以及一系列生物功能应用。虽然设计，合成，研究和利用CBM的专业知识主要是欧洲，但活跃于这一新兴领域工作的研究小组彼此独立。借助这项博士网络赠款，我们的目标是将这种专业知识团结在“欧洲超分子化学网络”（ENSCC）（ENSCC）中。凭借世界上大多数关于该主题的领先地位，以及三家率领该领域的技术，我们的ENSCC将成为欧洲强国，将在未来几年内在全球范围内领导学术领域。这将通过共享专业知识，密钥基础结构，分子构建块以及 - 重要的是 - 通过培训该博士网络赠款将资助的十个博士学位。由独特的世界领导者，该领域的专家以及对CBM感兴趣的公司进行的培训将使我们的博士生学生通过在学术界和/或行业中延续其职业生涯，从而使我们的博士生进一步发展该领域。