Metal-Organic Framework-Based Gas Sensors: Structural Engineering for Early Diabetes Diagnosis and Monitoring (SEEDDM)

基于金属有机框架的气体传感器：早期糖尿病诊断和监测的结构工程 (SEEDDM)

• 批准号: EP/Y002318/1
• 负责人: Sharel Peisan E
• 金额: $ 21.15万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY002318%2F1
• 关键词: Metal; Organic; Framework; Based; Gas

Diabetes is a tremendous health problem with 537 million cases worldwide in 2021 and contributing to millions of deaths each year. The annual global health expenditure on diabetes is expected to reach GBP 876 billion by 2045. Spectroscopic technologies (e.g. gas chromatography and mass spectrometry), alternative to invasive glucose blood testing, still dominate the non-invasive breath analysis market for diabetes screening and monitoring, however, these technologies are relatively expensive, slow, complex and require specialist skills to use and to interpret results. In comparison to those techniques, nanomaterials-based sensors (e.g. metal oxide semiconductor (MOS)) provide advantages such as simple, sensitivity, small size, ease of operation, and minimum maintenance requirements. However, most of the MOS-based sensors require high operating temperatures (200-500 oC) resulting in high energy consumption. Furthermore, MOSs only allow limited discrimination between different gases (e.g. alcohols and ketones) which cannot be determined without specialised spectroscopic techniques. Therefore, the development on the nanomaterials have been motivated. Metal-organic framework (MOF)-based materials are favourable due to their tunable pore sizes and shapes, high surface area, and nanopore structures, which allow easy diffusion of guest molecules into the highly-ordered frameworks, but the problems such as (mostly) their nonconducting characteristic, poor stability, unclarified and complicated gas sensing mechanism need to be solved, thus the innovation of structures for MOF-based electrodes calls for further exploration. The SEEDDM project will bring together internationally recognised researchers in heterojunction-based materials architectures and modelling from UM (Kuala Lumpur, Malaysia) and the expertise of UoE (Edinburgh, UK) in the development of porous nanomaterials to work on the conductive monolith metal-organic framework (MOF) coupled with suitable hydrogel electrolytes for breath (volatile organic compounds) VOC sensing in the applications of early diabetes diagnosis and monitoring. Our joint approach aims to solve the research challenges (synergy effects of conductive monolith MOF electrodes and hydrogel electrolytes to work at ultra-low power and room temperature environment) for the purpose of innovating inexpensive, portable, and high-performance devices. Diabetes biomarkers that could be detectable in breath are VOCs, which include acetone, isoprene, carbon monoxide, ammonia, and alkanes. Through collaboration with UM, state-of-the-art materials and device characterisation techniques will be used to understand the underlying mechanisms which will advance our ability to develop improved clinical decision, making personalised therapies combined increased levels of self-monitoring and diagnostics. The successful of this research will potentially ease the pressure of NHS on early diabetes screening and monitoring.After successfully fulfilling SEEDDM, we aim to innovate a portable, non-invasive breath analyser that exhibits high sensitivity (e.g. 0.05-3 ppm acetone detection at room temperature), high selectivity of target gases (e.g. ketone, alcohol), fast T90 response time (the time consumed when the gas detector changes from reading 0 to 90% of the full scale gas concentration) less than 60s, and stable cycle of more than 1,000 redox cycles (>85% humidity). Medical monitoring devices and wearable health technology have seen rapid growth over the past years (£17.5 billion in 2021 to £162.6 billion by 2030, a CAGR of 28.1%). Therefore, SEEDDM will not only help advance the quality of healthcare research and innovative efforts in the UK and Malaysia, but also strengthen and stimulate the development of new technologies in the healthcare industry.

糖尿病是一个巨大的健康问题，2021年全球5.37亿例病例，每年造成数百万人死亡。预计到2045年，全球糖尿病的全球健康支出预计将达到8760亿英镑。光谱技术（例如气体色谱和质谱法），可替代侵入性甘油血液测试的替代方案，仍然占主导地位的糖尿病和监测功能的非侵入性呼气分析市场，以及这些技术的较速度和较高的技能，以及相关的技能，以及较昂贵的技能，以及较稳定的技能，是相互访问的，以及较稳定的技能。与这些技术相比，基于纳米材料的传感器（例如金属氧化物半导体（MOS））提供了诸如简单，灵敏度，尺寸较小，操作易度和最小维护要求之类的优点。但是，大多数基于MOS的传感器都需要高工作温度（200-500 OC），从而导致高能消耗。此外，MOSS仅允许在没有专门的光谱技术的情况下确定不同气体（例如醇和酮）之间有限的歧视。因此，纳米材料的发展已融合。金属有机框架（MOF）的材料由于其可调的孔尺寸和形状，高表面积和纳米孔结构而受到利用，这些材料易于将客人分子易于扩散到高度有序的框架中，但诸如（大多数是）（大多数是）诸如不稳定的特征性，无能为力的稳定性，稳定的机制的构成方法，以至于诸如其稳定性的稳定性，因此是稳定性的，因此是稳定性的，是稳定的机制。电极要求进一步探索。 SEEDDM项目将汇集国际公认的基于异质结的材料架构和UM（马来西亚吉隆坡）的建模以及UOE（英国爱丁堡，英国）在多孔纳米材料中开发的UOE（英国爱丁堡）的专业知识，从在早期糖尿病诊断和监测的应用中感知。我们的联合方法旨在解决研究挑战（导电MOF电极和水凝胶电解质的协同效应以在超低功率和室温环境下工作），以实现目的的糖尿病生物标志物，可以在呼吸中检测到，其中包括VOC，其中包括丙烯，异戊二烯，碳氧化物，碳氧化物，氨基，氨基，丙烯氧化物，氧化碳和氨基和alkanes和Alkanes。通过与UM的合作，最先进的材料和设备表征技术将用于了解潜在的机制，这些机制将提高我们制定改进的临床决策的能力，从而使个性化疗法结合了自我监测和诊断水平的提高。 The successful of this research will potentially ease the pressure of NHS on early diabetes screening and monitoring.After successfully fulfilling SEEDDM, we aim to innovate a portable, non-invasive breath analyzer that exhibits high sensitivity (e.g. 0.05-3 ppm acetone detection at room temperature), high selectivity of target gases (e.g. ketone, alcohol), fast T90 response time (the time consumed when the gas检测器从读数的0到90％的全尺度气体浓度的变化）小于60s，稳定周期超过1,000个氧化还原周期（湿度> 85％）。在过去的几年中，医疗监测设备和可穿戴卫生技术的增长迅速（2021年的175亿英镑到2030年为1626亿英镑，复合年增长率为28.1％）。因此，SeedDM不仅将有助于提高英国和马来西亚的医疗保健研究和创新努力的质量，而且还可以加强和刺激医疗保健行业的新技术的发展。