DES AND CANCER OF VAGINA/CERVIX--COLLABORATIVE STUDIES

DES 与阴道/子宫颈癌——合作研究

• 批准号: 2104406
• 负责人: ARTHUR L HERBST
• 金额: $ 53.8万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2104406
• 关键词: cancer information system; cancer registry /resource; cervix neoplasms; diethylstilbestrol; drug related neoplasm /cancer; female; human mortality; human subject; neoplasm /cancer relapse /recurrence; vagina neoplasms

The data which are collected and analyzed in the Registry provide the sole comprehensive series of cases of DES-associated clear cell adenocarcinoma (CCA) for comparative and collaborative study. The specific aims are to update and enhance the data on currently accessioned cases of CCA; to maximize ascertainment of newly diagnosed cases; to add to the Registry women who have been treated but not previously accessioned, by collaborating with the DES Cancer Network (DCN - Collaborative Project A); to monitor the development of other mullcrian-derived primary cancers, such as cancer of the fallopian tube and endometrium to detect early any increase in occurrence; to serve as a source of information for treating physicians and patients; and to serve as a collaborating resource with NCI for other approved investigators who will rely on the Registry participants and/or data for research implementation. Once an expanded cohort has been established by adding all identify new cases of documented CCA, a questionnaire (approved by the Project Steering Committee) will be applied to all study participants. This questionnaire will incorporate new data for Registry as well as for the collaborating investigations. Additional topics to be investigated include extension of the age-incidence curve of CCA to older patients, updating the survival curve and investigation of factors affecting survival and recurrence including the complications of therapy. A collaborative trial through NCI will be sought to develop an improved regimen for recurrence therapy. Two additional collaborative projects are proposed. The first is a case- control study undertaken to assess risk factors for CCA among women exposed to DES, in particular, to assess the relation of oral contraceptive use, age at menarche, height, obesity, and season of birth. In addition, epidemiologic factors that may promote recurrence of CCA, in particular, the relation of height, obesity, cigarette smoking, and estrogen replacement therapy will be investigated, with emphasis on factors that may contribute to the development of late (greater than 8 years) recurrences. The second study will be to determine if human papillomavinus and p53 tumor suppressor gene alterations, currently linked to the natural history of non-clear cell carcinoma of the vagina and cervix, and associated with CCA.

登记处收集和分析的数据提供了 DES 相关透明细胞的唯一综合系列病例 腺癌（CCA）用于比较和合作研究。 具体目标是更新和增强当前的数据 CCA 的加入案例；最大限度地确定新诊断的 案例；将已接受治疗但尚未接受治疗的妇女添加到登记处 之前通过与 DES 癌症网络 (DCN - 合作项目A)；监控其他的发展 苗管源性原发性癌症，例如输卵管癌 和子宫内膜，以尽早发现发生率的增加；充当 治疗医生和患者的信息来源；并到 作为与 NCI 的合作资源，用于其他经批准的项目 调查人员将依赖登记处参与者和/或数据 研究实施。 一旦通过添加所有新识别来建立扩展队列 记录 CCA 的案例、调查问卷（经项目批准） 指导委员会）将适用于所有研究参与者。这 调查问卷将包含登记处和登记处的新数据 合作调查。 需要研究的其他主题 包括将 CCA 的年龄发病率曲线延伸至老年患者， 更新生存曲线并调查影响因素 生存和复发，包括治疗的并发症。一个 将寻求通过 NCI 进行合作试验，以开发改进的 复发治疗方案。 提议另外两个合作项目。第一个是案例—— 为评估女性 CCA 危险因素而进行的对照研究 暴露于 DES，特别是评估口腔的关系 避孕措施的使用、初潮年龄、身高、肥胖和月经季节 出生。 此外，流行病学因素可能会促进 CCA 的复发，特别是与身高、肥胖、 吸烟和雌激素替代疗法将 进行了调查，重点关注可能导致 晚期（超过 8 年）复发的发展。第二次研究 将确定人乳头状瘤病毒和p53肿瘤抑制因子是否 基因改变，目前与不明确的自然史有关 阴道和子宫颈细胞癌，并与 CCA 相关。