UHC/CWRU ADRC COMPETITIVE RENEWAL

UHC/CWRU ADRC 竞争性更新

• 批准号: 2049992
• 负责人: PETER John WHITEHOUSE
• 金额: $ 206.28万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-21 至 1998-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2049992
• 关键词: Alzheimer's disease

In its first four years of existence, our NIA ADRC has developed as a broad based research enterprise with major, local and national impact. Our proposal includes the four required cores: Administrative, Clinical, Neuropathology, Research Training and Information Transfer (RTIT). In addition to our existing Patient Registry and Data Management Analysis Components, our clinical core has grown with the recent competitively funded additions of a Psychopathology Assessment Component and NIA Satellite ADRC. Moreover, we have added an NIA funded Caregiver Core that provides data for clinical and social research on characteristics of the caregivers of our patents. Our RTIT core has expanded with competitive funding and considerable involvement from the local and national Alzheimer's Association. In this new application, six research projects are included. Two basic biological studies involve new, recently recruited senior faculty members in our center: G. Landreth the relationship between amyloid and glia; and K. Herrup on transgenic animal models of Alzheimer's disease (AD). Two other new projects involve C. Gilmore, studying the cognitive basis of visual disturbances in AD and D. Ripich evaluating communication in minority and nonminority caregivers; M. Patterson is leading efforts to characterize the behavioral symptoms of AD and K. Smyth is leading efforts in the use of services of caregivers with strong linkages to our two new cores. Our strong pilot program continues. Of over 50 faculty and other senior investigators involved with our AD research efforts at the University, many were introduced to the field through the pilot program. The renewal pilots as similarly broad in scope as our research projects ranging from basic biology (S. Younkin, amyloid processing) to clinical (J. Fagan, visual attention and K. Smyth, insight and denial of illness). Our proposed expansion of the NIA ADRC will allow us to continue our leadership role in the rapidly advancing national and international efforts to understand AD and improve the quality of lives of its victims.

在生存的头四年中，我们的NIA ADRC已发展为 基于主要，地方和国家影响的广泛研究企业。 我们的建议包括四个必需的核心：行政，临床， 神经病理学，研究培训和信息转移（RTIT）。 在 除我们现有的患者注册表和数据管理分析外 组件，我们的临床核心已随着最近的竞争性而发展 精神病学评估部分和NIA的资助增加 卫星ADRC。 此外，我们添加了NIA资助的护理人员核心 为临床和社会研究提供有关特征的临床和社会研究数据 我们专利的护理人员。 我们的RTIT核心已扩展 竞争性资金和当地和相当大的参与 国家阿尔茨海默氏症协会。 在这个新应用程序中，六项研究 包括项目。 两项基本的生物学研究涉及新的 最近招募了我们中心的高级教师：G。Landreth 淀粉样蛋白和神经胶质之间的关系；和K. Herrup对转基因动物 阿尔茨海默氏病模型（AD）。 其他两个新项目涉及C。 吉尔莫尔（Gilmore），研究AD和D的视觉障碍的认知基础。 Ripich评估少数民族和非少数群体照顾者的交流； M. Patterson正在领导着表征行为症状的努力 Ad和K. Smyth的领导 与我们的两个新核心有着紧密联系的护理人员。 我们强大的飞行员 程序仍在继续。 超过50位教职员工和其他高级调查员 参与了大学的广告研究工作，许多是 通过试点计划介绍了该领域。 更新飞行员 同样广泛的范围，我们的研究项目从基本 生物学（S. Younkin，淀粉样蛋白加工）至临床（J. Fagan，Visual 注意力和K. Smyth，洞察力和否认疾病）。我们提出的 NIA ADRC的扩展将使我们能够继续我们的领导角色 在迅速发展的国家和国际努力中 广告并改善受害者的生活质量。