SCOR IN SYSTEMIC LUPUS ERTHEMATOSUS

系统性红斑狼疮的 SCOR

• 批准号: 2081931
• 负责人: ROBERT A. EISENBERG
• 金额: $ 51.54万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2081931
• 关键词: antibody formation; autoantibody; immune tolerance /unresponsiveness; immunoregulation; systemic lupus erythematosus

The current application requests support to create a Specialized Center of Research (SCOR) in Systemic Lupus Erythematosus at the University of North Carolina at Chapel Hill. Our proposal will unite seven investigators with previous strong backgrounds in SLE research (Drs. Eisenberg, Clarke, Cohen, Dooley, Falk, Reeves,and Winfield) in four projects directed at furthering our understanding of the immunoregulation of autoantibody production in SLE. We will investigate both human disease and murine models, and we will combine expertise in clinical research, cellular immunology, immunochemistry, immunogenetics, and the molecular biology of autoantibodies and autoantigens. An administrative core will support the overall direction of the SCOR (Dr. Eisenberg, Director, and Dr. Winfield, Assistant Director) and provide secretarial and accounting services for the four projects. The SCOR will receive support from the Division of Rheumatology, the Multipurpose Arthritis Center, and the Thurston Arthritis Center, and its functions will be efficiently integrated with these existent entities through their director, Dr. Winfield. The projects of the SCOR are: Project 1: Anti-Sm B Cells of MRL/lpr Mice," Dr. Clarke, PI, which will investigate the immunogenetics of autoantibody genes and the immunoregulation of the mice; Project 2: "Programmed Cell Death and Systemic Autoimmunity," Dr. Cohen, PI, which will investigate the role of apoptosis in self tolerance and in the release of autoantigens; Project 3: "Preserving Ovarian Function in Lupus Nephritis Therapy," Drs. Falk and Dooley, co-PIs, which will test whether chemically induced temporary menopause can protect against the sterilizing effects of cyclophosphamide therapy and downregulate active SLE; and Project 4: "Positive Feedback Regulation of Autoantibody Production," Dr. Reeves, PI, which will isolate genes for several autoantigens and investigate how antibodies to such proteins can be induced by other autoantibodies. The further understanding of the regulation of autoantibody production will eventually permit the design of specific therapies in human SLE.

当前的申请请求支持以创建一个专门的中心 北大学全身性红斑狼疮的研究（SCOR） 卡罗来纳州教堂山。我们的建议将与七名调查员团结起来 以前的SLE研究背景强大（Eisenberg博士，Clarke， Cohen，Dooley，Falk，Reeves和Winfield在四个针对的项目中 进一步了解自身抗体的免疫调节 SLE的生产。我们将研究人类疾病和鼠 模型，我们将结合临床研究中的专业知识，细胞 免疫学，免疫化学，免疫遗传学和分子生物学 自身抗体和自动抗原。行政核心将支持 SCOR的总体指导（艾森伯格博士，主任和温菲尔德博士， 助理主任），为秘书和会计服务提供 四个项目。 SCOR将获得部门的支持 风湿病学，多功能关节炎中心和瑟斯顿 关节炎中心及其功能将有效地与 这些存在的实体通过其导演温菲尔德博士。项目 SCOR的是：项目1：MRL/LPR小鼠的抗SM B细胞，” Clarke博士， PI，将研究自身抗体基因的免疫遗传学和 小鼠的免疫调节；项目2：“编程细胞死亡和 系统性自身免疫性，” PI Cohen博士将研究 自耐力的凋亡和自身抗原的释放；项目3： “保留狼疮肾炎疗法中的卵巢功能，” Drs。福克和 Dooley，Co-Pis，它将测试是否化学诱导临时性 更年期可以预防环磷酰胺的灭菌作用 治疗和下调活跃的SLE；和项目4：“积极的反馈 自身抗体生产的调节，” Reeves，Pi，将隔离 几种自身抗原的基因，并研究了这种抗体 蛋白质可以由其他自身抗体诱导。进一步的理解 自身抗体生产的调节最终将允许 人类SLE中特定疗法的设计。