PHARAMACOKINETICS OF ORAL MYCOPHENOLATE MOFETIL IN RENAL TRANSPLANT PATIENTS

肾移植患者口服麦酚酸酯的药代动力学

• 批准号: 3743663
• 负责人: J THOMAS ROSENTHAL
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3743663
• 关键词: circadian rhythms; diet route /schedule; human subject; kidney transplantation; mycophenolic acid; nutrition related tag; oral administration; pharmacokinetics

The objective of this study is to determine the steady-state pharmacokinetics of oral mycophenolate mofetil in stable renal transplant recipients and to determine if standardized meals or diurnal factors affect these pharmacokinetics following each of two oral doses separated by 7-28 days.

本研究的目的是确定稳态 口服吗替麦考酚酯在稳定肾移植中的药代动力学 接受者并确定是否标准化膳食或昼夜因素 两次口服剂量分开后影响这些药代动力学 7-28 天。